目的 探討美羅培南治療膿毒癥休克的臨床療效。方法 回顧性分析2013年12月-2016年12月安康市中心醫(yī)院收治的膿毒性休克患者120例，根據(jù)治療方法的不同分為兩組，每組60例。對(duì)照組患者給予液體復(fù)蘇、升血壓、抗炎等對(duì)癥治療，及時(shí)進(jìn)行血液濾過治療，同時(shí)接受其他廣譜抗生素抗感染治療。觀察組在液體復(fù)蘇、升血壓、抗炎、血液凈化等治療基礎(chǔ)上泵入美羅培南，將2 g注射用美羅培南溶于50 mL生理鹽水中，使用微量注射泵持續(xù)泵入，持續(xù)8 h泵入完成，每日2次。評(píng)價(jià)兩組患者治療的臨床療效，并且采用感染相關(guān)的器官衰竭評(píng)分系統(tǒng)（SOFA）標(biāo)準(zhǔn)評(píng)價(jià)兩組患者治療后的器官衰竭程度，分別檢測(cè)并比較兩組患者治療前后免疫炎癥相關(guān)因子的水平。結(jié)果 觀察組患者的治療總有效率為88.33%，顯著高于對(duì)照組的73.33%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。經(jīng)治療，兩組患者的血清降鈣素原（PCT）、C反應(yīng)蛋白（CRP）及SOFA評(píng)分等較治療前顯著降低，組內(nèi)差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組上述指標(biāo)顯著低于對(duì)照組，組間差異有統(tǒng)計(jì)學(xué)意義（P<0.05）經(jīng)治療，觀察組抗菌療效的細(xì)菌總清除率為86.67%，顯著高于對(duì)照組的71.67%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 美羅培南治療膿毒癥休克抗菌效應(yīng)及臨床療效顯著，值得臨床推廣應(yīng)用。

Objective:To explore the curative effect of meropenem for septic shock. Methods 120 patients with septic shock were enrolled in our hospital from December 2013 to December 2016, of which all patients conducted conventional treatment and divided into two groups randomly, and control group (n=60) accepted another broad-spectrum antibiotics based conventional treatment, and study group (n=60) adopted meropenem treatment. The clinical curative effect were evaluated and analyzed, and the organ failure degree of two groups were evaluated via sepsis-related organ failure assessment (SOFA) gauge in post-treatment. The inflammatory factors of all patients were detected and analyzed respectively before and after treatment. Results The total effective rate of study group was higher significantly than that control group (P < 0.05). After treatment, the serum procalcitonin (PCT), C-response protein (CRP) and SOFA score decreased significantly (P < 0.05), and which indexes of study group were lower significantly than those patients in control group (P < 0.05). The total bacterial clearance of study group was higher than that control group, and which difference between two groups was significance (P < 0.05). Conclusions The antibacterial effect and clinical efficacy of meropenem were remarkable, and which deserved popularization in clinic.