腫瘤多藥耐藥（multidrug resistance，MDR）對腫瘤的藥物治療的療效有嚴(yán)重的影響。多藥耐藥擁有十分復(fù)雜的發(fā)生發(fā)展的機(jī)制。通過討論自噬與藥物抗腫瘤時(shí)的相互影響，旨在闡明自噬與腫瘤細(xì)胞多藥耐藥的關(guān)系，為今后抗腫瘤藥物治療的臨床應(yīng)用提供新的思路。

Tumor multidrug resistance (MDR) has seriously affected the efficacy of drug therapy on tumors. The occurrence of multidrug resistance has a very complex mechanism. In this paper, we discuss the relationship between autophagy and drug anti-tumor, aiming to elucidate the relationship between autophagy and multidrug resistance in tumor cells, and provide new ideas for the clinical application of anticancer drugs.

國家自然科學(xué)基金項(xiàng)目（81473280）