S)和藥物吸收率(V)。結(jié)果 浴槽中給予低、中、高濃度的總黃酮溶液后,隨著時間的延長,腸囊內(nèi)V逐漸增加,但均較小,最大吸收率分別為8.74%、8.15%、8.77%,組間無統(tǒng)計(jì)學(xué)差異;在0~180 min內(nèi),低、中、高濃度QS持續(xù)增加,最大值分別為32.00、63.49、115.29 μg/cm2,45~180 min高濃度組顯著大于低濃度組(P < 0.01)。結(jié)論 金蓮花中的總黃酮不易被機(jī)體吸收,其吸收特征與其單體化合物一致。;Objective To investigate the absorption properties of the total flavonoids from the flowers of Trollius chinensis for the purpose of the evaluation of the main effective components of these flowers and their further development and utilization. Methods The everted gut sac model was established, and the total flavonoids in Tyrode solution of 2, 6, and 10 mg/mL were given in the bath. Sample of 100 μL were taken from the intestinal sac 15, 30, 45, 60, 90, 120, 150, and 180 min after receiving, and the same volume blank Tyrode solution was added. The sample was processed as a test solution. Using orientin as control sample, the content of total flavonoids in the samples was determined by using microplate reader at 341 nm, and cumulative absorption quantities of the total flavonoids per unit area (QS) and the drug absorption rate (V) were calculated. Results Given the total flavone solution of low, middle and high concentration in the bath, V of intestinal sac increased gradually with the extension of time, and the maximum absorption rate were 8.74%, 8.15%, 8.77%, respectively, but there were no significant differences among groups. During the period of 0 to 180 min, QS of low, medium and high concentration increased sustainably with the maximum values of 32.00, 63.49, and 115.29 μg/cm2, respectively. During the period of 45 to 180 min, QS of high concentration group was significantly higher than that in the low concentration group (P < 0.01). Conclusion The total flavonoids from the flowers of T. chinensis are not easily absorbed by the organism, and their absorption properties are consistent with those of the monomeric compounds."/>

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首頁 > 過刊瀏覽>2018年第41卷第1期 >2018,41(1):83-87. DOI:10.7501/j.issn.1674-6376.2018.01.014
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外翻腸囊法研究金蓮花總黃酮的吸收特征

Absorption properties of total flavonoids from flowers of Trollius chinensis in rat everted gut sacs

發(fā)布日期:2018-03-17
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