0-)顯著增大、延遲時間(tlag)為5.307 h,顯著延長(P < 0.05),參比制劑的達(dá)峰時間(tmax)為3 h,受試制劑tmax為16 h,兩組差異顯著(P < 0.05)。受試制劑的Fr為74.0%,其Cmax為參比制劑的62.6%,二者間均不具生物等效性。結(jié)論 克癌素結(jié)腸定位包衣滴丸具有典型的緩(控)釋特征,姜黃素成分結(jié)腸段蓄積,具有良好的靶向結(jié)腸定位效果。;Objective To evaluate the pharmacokinetics of quercetin of anti-cancer factor on colon-targeting coating dropping pills in rabbit model in vivo. Methods Totally six rabbits were randomly divided into two groups:test preparation group and reference preparation group. Rabbits in test preparation group were ig administered with anti-cancer factor colon-targeting coating dropping pills, and rabbits in reference preparation group were ig administered with core of dropping pills, each group with a single dose of 120 pills (1.5 mg curcumin per pill). Blood was taken from the carotid artery at different time after administration. A high performance liquid chromatography (HPLC) method was established for detection of curcumin in plasma for further verification of methodology. The blood concentration of curcumin at different time points was determined, and the time curve was drawn. The main pharmacokinetic parameters were calculated by DAS 2.1 software, and the relative availability (Fr) of the test preparations was calculated according to the pharmacokinetic parameters. Results The established HPLC method meets the detection requirements. The drug time curve showed that the reference preparation conformed to the double chamber model and had no lag time, but the test preparation conformed to the one room model and had the lag time. The pharmacokinetic parameters showed that, compared with reference preparation, the area under the curve (AUC0-) of test preparation increased significantly (P < 0.05), and the delay time (Tlag) prolonged significantly (P < 0.05), which was 5.307 h. Moreover, there was a significance difference between the time to peak (Tmax) of reference preparation and test preparation (P < 0.05), which is 3 h and 16 h respectively. The Fr of test preparation was 74%, and its Cmax was 62.6% of that of reference preparation, and no bioequivalence was found between the two. Conclusion Anti-cancer factor on colon-targeting coating dropping pills possess typical slow and controlled releasing characteristic. The accumulation of curcumin in the colon segment has good colon-targeting effect. Thereby improving the efficacy, reduce toxicity, with a good targeting colon positioning effect."/>

醉酒后少妇被疯狂内射视频,一本色道久久综合一,在线天堂新版资源www在线下载,中文字幕乱人伦高清视频,中字幕视频在线永久在线观看免费

首頁 > 過刊瀏覽>2018年第41卷第1期 >2018,41(1):88-92. DOI:10.7501/j.issn.1674-6376.2018.01.015
上一篇 | 下一篇

克癌素結(jié)腸包衣滴丸中姜黃素在家兔體內(nèi)的藥動學(xué)研究

Study on pharmacokinetics of quercetin of anti-cancer factor on colon coating dropping pills in rabbits

發(fā)布日期:2018-03-17
您是第位訪問者
藥物評價研究 ® 2025 版權(quán)所有
技術(shù)支持:北京勤云科技發(fā)展有限公司
津備案:津ICP備13000267號 互聯(lián)網(wǎng)藥品信息服務(wù)資格證書編號:(津)-非經(jīng)營性-2015-0031