目的 探討加巴噴丁膠囊聯(lián)合小劑量潑尼松治療對帶狀皰疹患者清神經(jīng)肽Y（NPY）、P物質(zhì)（SP）及T細胞亞群的影響及近期臨床療效。方法 選擇海南省人民醫(yī)院2015年1月-2016年12月期間收治的帶狀皰疹患者128例，隨機數(shù)表法分為對照組與觀察組，每組各64例。其中對照組患者給予小劑量潑尼松治療，觀察組患者給予加巴噴丁膠囊聯(lián)合小劑量潑尼松治療。比較兩組患者近期療效，治療前后患者視覺模擬尺評分（VAS）、T淋巴細胞亞群變化情況（CD3⁺和CD4⁺、CD8⁺、CD4⁺/CD8⁺）及NPY和SP水平。結(jié)果 經(jīng)不同方案治療后，觀察組的總有效率為95.31%，對照組總有效率為85.94%，兩組相比差異顯著且具有統(tǒng)計意義（χ²=8.67，P < 0.05）。與治療前相比，兩組患者治療后的VAS評分顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P < 0.05）；治療后，觀察組VAS評分顯著低于對照組，差異有統(tǒng)計學(xué)意義（P < 0.05）。與治療前相比，兩組患者治療后T淋巴細胞亞群CD3⁺和CD4⁺、CD4⁺/CD8⁺明顯增高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P < 0.05）；觀察組治療后T淋巴細胞亞群CD3⁺和CD4⁺、CD4⁺/CD8⁺較對照組增加更顯著，差異有統(tǒng)計學(xué)意義（P < 0.05）。兩組NPY和SP水平較治療前均顯著下降，同組治療前后比較差異有統(tǒng)計學(xué)意義（P < 0.05）；治療后，觀察組NPY和SP水平均顯著低于對照組，差異有統(tǒng)計學(xué)意義（P < 0.05）。結(jié)論 加巴噴丁膠囊聯(lián)合小劑量潑尼松治療對帶狀皰疹患者能夠有效改善患者臨床癥狀，緩輕患者的神經(jīng)疼痛，改善患者機體免疫功能功能，降低外周血NPY、SP水平，值得臨床推廣和應(yīng)用。

Objective To investigate the effect of gabapentin capsules with low dosage of prednisone on T lymphocyte subsets and serum NPY and SP levels in the patients with shingles, and its recent therapeutical effect. Methods 128 cases of patients with shingles were selected from Jan. 2015 to Dec. 2016 in our hospital. Patients were divided into control group and observation group according to random number table method with 64 cases, respectively. Patients in control group were treated with low dosage of prednisone. Patients in observation group were treated with gabapentin capsules with low dosage of prednisone. The recent therapeutical effect, the VAS scores, the change of T lymphocyte subsets (including CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺) and the serum NPY and SP levels were observed in the two groups before and after treatment. Results The recent therapeutical effect rate of observation group was 95.31%, and the recent therapeutical effect rate of control group was 85.94% after treatment with different options, and the difference was statistically significant between two groups (χ²=8.67, P < 0.05). After treatment, the VAS scores of two groups were significantly lower than the pre-therapy, and the observation group were significantly lower than the control group. The indexes of T lymphocyte subsets CD3⁺, CD4⁺, CD8⁺ and CD4⁺/CD8⁺ in two group were significantly increased compared with pre-therapy, and the observation group were significantly increased compared with control group. And the serum NPY and SP levels were significantly decreased compared with pre-therapy, and the observation group were significantly decreased compared with the control group. The difference was statistically significant between two groups (P < 0.05). Conclusion gabapentin capsules with low dosage of prednisone can effectively improve the recent therapeutical effect in the treatment of the patients with shingles, and reduce the nerve pain, and improve the immune function, and decrease the serum NPY and SP levels. And it is worthy of clinical promotion and application.