目的 探討基質(zhì)細胞衍生因子-1（SDF-1）與N末端腦鈉肽原（NT-proBNP）對圍生期心肌病的評估價值。方法 選擇2012年2月-2017年1月在南陽市第二人民醫(yī)院產(chǎn)科診治的圍生期心肌病患者60例作為觀察組，同期選擇在該院進行體檢的圍生期婦女60例作為對照組，兩組都進行SDF-1與NT-proBNP檢測，同時進行超聲觀察與判斷。結(jié)果 觀察組的左房內(nèi)徑和室間隔厚度都明顯高于對照組，差異有統(tǒng)計學(xué)意義（P < 0.05）；兩組右室內(nèi)徑與左心室射血分數(shù)對比差異無統(tǒng)計學(xué)意義。觀察組與對照組的血清NT-proBNP濃度分別為（2.22±0.33）pg/mL和（1.13±0.24）pg/mL，觀察組明顯高于對照組，差異有統(tǒng)計學(xué)意義（P < 0.05）。觀察組的SDF-1 3'A基因型頻率為41.7%（25/60），對照組為20.0%（12/60），觀察組明顯高于對照組，差異有統(tǒng)計學(xué)意義（P < 0.05）。logistic回歸分析顯示NT-proBNP、SDF-1 3'A基因型、左心室射血分數(shù)都為導(dǎo)致圍生期心肌病發(fā)生的主要獨立危險因素（P < 0.05）。結(jié)論 SDF-1與NT-proBNP對圍生期心肌病有很好的評估價值，能有效判斷疾病狀況，也是圍生期心肌病發(fā)生的獨立危險因素。

Objective To investigate the value of SDF-1 and NT-proBNP in the evaluation of peripartum cardiomyopathy. Methods From February 2012 to January 2017, 60 patients of peripartum cardiomyopathyin our hospital diagnosis and treatment were selected as the observation group, 60 women in perinatal period were selected as control group at the same period, The SDF-1 and NT-proBNP in the two groups were detected, and were all given ultrasonic detection and judgment. Results The left atrial diameter and interventricular septal thickness in the observation group were significantly higher than those in the control group (P < 0.05), and there were no significant difference compared between the two groups of right ventricular diameter and left ventricular ejection fraction. The serum NT-proBNP lelves in the observation group and the control group were (2.22±0.33) pg/mL and (1.13±0.24) pg/mL, respectively, and the observation group were significantly higher than that of the control group (P < 0.05). The frequency of SDF-1 3, A genotype was 41.7% (25/60) in the observation group, and was 20% (12/60) in the control group, The observation group was also significantly higher than that of the control group (P < 0.05). Logistic regression analysis showed that NT-proBNP, SDF-1 3, A genotype and left ventricular ejection fraction were the major independent risk factors for peripartum cardiomyopathy (P < 0.05). Conclusion SDF-1 and NT-proBNP have good evaluation value for peripartum cardiomyopathy, they can effectively judge the disease status, and are also independent risk factors of peripartum cardiomyopathy.