目的 對比瑞舒伐他汀鈣與阿托伐他汀鈣對動脈粥樣硬化急性腦梗死合并高血脂的臨床療效。方法 選擇2015年4月-2016年10月濮陽市人民醫(yī)院收治的動脈粥樣硬化急性腦梗死合并高血脂患者102例，根據隨機數(shù)字表法，平均分為瑞舒伐他汀鈣組和阿托伐他汀鈣組。比較兩組治療前及治療后的肝功能、血糖及血脂等指標，以及治療后的不良反應及神經功能缺損評分（NIHSS）。結果 與阿托伐他汀鈣組相比，瑞舒伐他汀鈣組的有效率明顯較高，差異有統(tǒng)計學意義（P < 0.05）。兩組治療后肝功能、血糖、血脂、CK指標及NIHSS評分均優(yōu)于治療前，同組治療前后比較差異有統(tǒng)計學意義（P < 0.05）。治療后兩組肝功能、血糖、三酰甘油（TG）、總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）、肌酸激酶（CK）指標及不良反應對比無統(tǒng)計學意義；而治療后瑞舒伐他汀鈣組的低密度脂蛋白膽固醇（LDL-C）及NIHSS評分均明顯優(yōu)于阿托伐他汀鈣組，差異有統(tǒng)計學意義（P < 0.05）。結論 瑞舒伐他汀鈣與阿托伐他汀鈣治療動脈粥樣硬化急性腦梗死合并高血脂癥療效相當，而瑞舒伐他汀鈣在改善神經功能及LDL-C指標方面優(yōu)于阿托伐他汀鈣。

Objective To compare the clinical efficacy of rosuvastatin calcium and atorvastatin calcium in treatment of atherosclerosis acute cerebral infarction combined with hyperlipidemia. Methods 102 cases with rosuvastatin calcium and atorvastatin calcium in People's Hospital of Puyang from Apr. 2015 to Oct. 2016 in our hospital were chosen, who were divided into the rosuvastatin calcium group and atorvastatin calcium group. The liver function indexes, blood glucose and blood lipid of two groups before and after treatment were compared, the adverse reactions and NIHSS score of two groups after treatment were compared. Results Compared with atorvastatin calcium, the rosuvastatin calcium total efficacy was higher (P < 0.05). The liver function indexes, blood glucose, blood lipid, CK and NIHSS score of two groups after treatment were better than before treatment (P < 0.05). The liver function indexes, blood glucose, TG, TC, HDL-C, CK and NIHSS scores of two groups had no significant difference,. The LDL-C and adverse reactions of two groups after treatment had no significant difference (P < 0.05). Conclusion Rosuvastatin calcium and atorvastatin calcium in treatment of atherosclerosis acute cerebral infarction combined with hyperlipidemia were therapeutic equivalence, while the rosuvastatin calcium could improve the neurological function and LDL-C better than atorvastatin calcium.