熊果酸具有廣泛的藥理作用，包括抗炎、抗變態(tài)反應(yīng)，抗腫瘤，保護(hù)心、血管、肝、腎、肺，抗糖尿病、調(diào)血脂抗肥胖，抗動(dòng)脈粥樣硬化等。但是其口服的生物利用度低，通過(guò)被動(dòng)擴(kuò)散被腸道吸收；將熊果酸制成分散體制劑能提高溶出度和生物利用度，且能濃集于肝臟，有利于治療肝部疾病。綜述熊果酸的藥動(dòng)學(xué)參數(shù)、體內(nèi)過(guò)程和熊果酸分散體的藥動(dòng)學(xué)特征，總結(jié)其藥動(dòng)學(xué)研究進(jìn)展，為合理用藥提供參考。

Ursolic acid has a widespread pharmacologic effect, including anti-inflammation, anti-allergy, antitumor, protection of heart, blood vessel, liver, kidney, lung, antidiabetes, lipidemic regulation and anti-obesity, antiatherosclerosis, anti-hepatic steatosis and fibrosis, etc. Bioavailability of ursolic acid by oral administration is low since it is absorbed by intestine through passive diffusion. Ursolic acid dispersion preparation can increase its solubility and bioavailability, and concentrate on liver to help treat for hepatic disease. In this paper, the pharmacokinetic parameters, the process of ursolic acid in vivo, and the pharmacokinetic feature of ursolic acid dispersion are reviewed, and its research advance on pharmacokinetics is summarized, in order to provide a reference for rational utilization of ursolic acid.