目的 探討丙氨酰谷氨酰胺對危重有機(jī)磷中毒患者免疫功能及神經(jīng)功能的影響。方法 將榆林市第一醫(yī)院自2012年1月-2016年12月收治的86例危重有機(jī)磷中毒患者作為研究對象，隨機(jī)分為對照組和研究組，每組43例，對照組患者采用復(fù)能劑氯解磷定、解毒劑阿托品、血液灌流以及其他對癥治療，研究組患者在對照組治療的基礎(chǔ)上靜脈注射丙氨酰谷氨酰胺注射液，連續(xù)治療3 d后觀察兩組患者的臨床效果、神經(jīng)功能、免疫功能等指標(biāo)。結(jié)果 研究組患者中毒癥狀消失時間、全血膽堿酯酶恢復(fù)時間、住院時間、F波潛伏期均顯著少于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后研究組患者腓總神經(jīng)的運(yùn)動神經(jīng)傳導(dǎo)速度（MCV）、感覺神經(jīng)傳導(dǎo)速度（SCV）水平均顯著高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。兩組IgG、IgA、IgM、TLC等指標(biāo)相比于治療前顯著升高，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且研究組顯著高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 丙氨酰谷氨酰胺可以使重癥有機(jī)磷中毒患者的臨床癥狀得到緩解，改善神經(jīng)功能及免疫功能，效果顯著，可推廣使用。

Objective To investigate the effect of alanylglutamine on immune function and neurological function in critically ill organophosphate poisoning patients.Methods 86 cases of critically ill organ ophosphorus poisoning patients admitted in our hospital from January 2012 to December 2016 were randomly divided into study group and control group. The control group was given Antiperspirant atropine, complex agent chlorpheniramide, hemoperfusion and other symptomatic treatment, the study group of patients in the control group based on the intravenous injection of alanyl glutamine injection, continuous treatment three days after two groups of patients observed clinical effects and immune function and neurological function and other indicators.Results The time of disappearance of poisoning symptoms, the recovery time of cholinesterase in whole blood and the time of hospitalization were significantly lower than those of the control group (P< 0.05). After treatment, the levels of MCV and SCV were significantly higher in the study group than those in the control group (P< 0.05). The scores of IgG, IgA, IgM and TLC in the study group were significantly higher than those in the control group before, and the difference was statistically significant (P< 0.05).Conclusion Alanylglutamine can effectively relieve the clinical symptoms of patients with severe organophosphate poisoning, improve neurological function and immune function, the effect is remarkable, can be used.