目的 評價疏風(fēng)解毒膠囊口服加外用聯(lián)合治療激素依賴性皮炎的臨床效果。方法 2013年6月-2015年5月重慶市職業(yè)病防治院皮膚科診治的激素依賴性皮炎患者，按就診時間分入疏風(fēng)解毒組與他克莫司組，所有患者停用激素類藥物及可疑含激素化妝品，并進(jìn)行心理安撫治療，告知治療過程中可能出現(xiàn)的反應(yīng)癥狀。疏風(fēng)解毒組予疏風(fēng)解毒膠囊口服，4粒/次，3次/d，同時予3粒疏風(fēng)解毒膠囊去除膠囊200 mL溫水溶解后面部濕敷，>4次/d，療程4周；他克莫司組0.1%他克莫司軟膏，早晚各1次，療程4周。療程結(jié)束后，未達(dá)到有效治療的患者予兩組方案交替治療，繼續(xù)治療4周。觀察兩組臨床治療效果，對所有達(dá)到有效治療的患者隨訪至論文撰寫階段了解治療效果。結(jié)果 疏風(fēng)解毒組共診治39例，第1階段有效率87.2%，他克莫司組36例，第1階段有效率達(dá)68.6%，疏風(fēng)解毒組有效率高于他克莫司組，差異有統(tǒng)計學(xué)意義（P<0.05）；第一階段未能達(dá)到有效治療的患者，在交替治療方案后均達(dá)到有效治療。隨訪階段，疏風(fēng)解毒組平均隨訪時間為（7.9±2.7）月，有6例患者復(fù)發(fā)，平均復(fù)發(fā)時間為（6.8±1.4）月，復(fù)發(fā)時癥候積分為（10.3±2.9）分；他克莫司組隨訪時間為（7.6±1.8）月，有13例復(fù)發(fā)，平均復(fù)發(fā)時間為（5.1±1.8）月，復(fù)發(fā)時癥候積分為（13.2±2.2）分。疏風(fēng)解毒組復(fù)發(fā)率、復(fù)發(fā)癥候積分均小于他克莫司組，差異有統(tǒng)計學(xué)意義（P<0.05）；復(fù)發(fā)時間大于他克莫司組，差異有統(tǒng)計學(xué)意義（P<0.05）；兩組隨訪時間差異比較無統(tǒng)計學(xué)意義。他克莫司組開始治療時有3例患者出現(xiàn)輕微皮膚灼熱、刺痛，不影響治療，對癥處理后不適癥狀消失，疏風(fēng)解毒膠囊治療組未見不良反應(yīng)。結(jié)論 疏風(fēng)解毒膠囊內(nèi)外聯(lián)合治療激素依賴性皮炎療效確切，能減少激素依賴性皮炎復(fù)發(fā)，即可作為首選治療，也可作為其他治療失敗后的補(bǔ)充治療。

Objective To evaluate the clinical effect of Shufeng Jiedu capsules for oral and external use in the treatment of hormone dependent dermatitis.Methods From 2013-6 to 2015-5, all patients with hormone dependent dermatitis were divided into Shufeng Jiedu group and Tacrolimus group. All patients discontinued hormone drugs, cosmetics containing hormone, and gained psychotherapy. Shufeng Jiedu group with Shufeng Jiedu capsules. Tacrolimus group with 0.1% tacrolimus ointment. The course of treatment for 4 weeks. After the treatment for 4 weeks. If the patients without effective therapy, we alternated the treatment in the two groups for 4 weeks. The clinical curative effect would be evaluated.Results 39 patients in the Shufeng Jiedu group, the effective rate was 87.2% in the first stage; 36 patients in the tacrolimus group, the effective rate was 68.6% in the first stage (P< 0.05). All patients without effective treatment would gain better after the altnative use of Shufeng Jiedu Capsules and tacrolimus ointment. There were no difference in follow-up period between two groups. There were 6 patients in recurrence in the Shufeng Jiedu group, the recurrence time was (6.8 ±1.4) months, recurrence syndrome integral was (10.3 ±2.9). There were 13 patients in recurrence in Tacrolimus group,the recurrence time was (7.6 ±1.8) months, recurrence syndrome integral was (13.2 ±2.2). The recurrence rate and recurrence syndrome integral of Shufeng Jiedu group were less than these of tacrolimus group (P< 0.05), the recurrence time of Shufeng Jiedu group was better than that of tacrolimus group (P< 0.05). Three patients with mild skin burning and tingle when starting treatment in the Tacrolimus group, but no effect on treatment. Shufeng Jiedu group without adverse reactions.Conclusions There would have a good effect on hormone dependence dermatitis by Shufeng Jiedu capsules for oral and external use, and could reduce the recurrence.