目的 評(píng)價(jià)甘精胰島素聯(lián)合門冬胰島素治療對(duì)2型糖尿病患者的血糖控制效果。方法 選取上海市長(zhǎng)寧區(qū)天山中醫(yī)醫(yī)院內(nèi)分泌科2013年1月-2016年1月治療的2型糖尿病患者150例，隨機(jī)分為兩組（n=75）。其中對(duì)照組75例采用精蛋白生物合成人胰島素注射液聯(lián)合三餐門冬胰島素治療；試驗(yàn)組75例采用甘精胰島素聯(lián)合三餐門冬胰島素治療，均用藥6個(gè)月。比較兩組治療前后空腹血糖、餐后2 h血糖和糖化血紅蛋白（HbA1c）水平、兩組生存質(zhì)量和不良反應(yīng)情況。結(jié)果 治療6個(gè)月時(shí)，對(duì)照組和試驗(yàn)組患者的空腹血糖、餐后2 h血糖和HbA1c水平均較同組治療前降低（P<0.05），且試驗(yàn)組的空腹血糖和HbA1c水平均低于對(duì)照組的（P<0.05），試驗(yàn)組生存質(zhì)量明顯優(yōu)于對(duì)照組（P<0.05）；治療3個(gè)月時(shí)，試驗(yàn)組的HbA1c水平低于對(duì)照組的，差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。試驗(yàn)組輕微低血糖、夜間低血糖和心腦血管發(fā)生率明顯低于對(duì)照組（P<0.05）。結(jié)論 甘精胰島素聯(lián)合門冬胰島素治療對(duì)2型糖尿病患者的血糖控制效果顯著，可長(zhǎng)時(shí)間將血糖穩(wěn)定在正常水平，患者不良反應(yīng)發(fā)生率低、生存質(zhì)量高。

Objective To explore the effect of insulin glargine combined with insulin aspart treatment on blood glucose control in type 2 diabetic patients.Methods A total of 150 cases of patients with type 2 diabetes who underwent treatment in department of Endocrinology, Tianshan Traditional Chinese Medicine Hospital from January 2013 to January 2016 were selected and divided into control group and experiment group by a random number table method, with 75 cases in each group. Patients in the control group were treated with Novolin N combined with insulin aspart. Patients in the experiment group were treated with the insulin glargine combined with insulin aspart. The levels of fasting blood glucose, postprandial 2 h blood glucose and glycosylated hemoglobin (HbA1c) were compared before and after treatment in the two groups, and the quality of life and adverse reactions in the two groups were analyzed.Results At treatment of six months, the levels of fasting blood glucose, postprandial 2 h blood glucose and HbA1c were lower in two groups than those before treatment (P< 0.05), while the levels of fasting blood glucose and HbA1c in the experimental group was lower than those in the control group (P< 0.05). The quality of life in the experimental group was obviously better than that of the control group (P< 0.05). At treatment of three months, the level of HbA1c in experiment group was lower than that in control group (P< 0.05), the differences in which were statistically significant (P< 0.05).The incidence of mild hypoglycemia, nocturnal hypoglycemia and cardio-cerebral vascularization in the experimental group was significantly lower than those in the control group (P< 0.05).Conclusion Insulin glargine combined with insulin aspart has a significant effect on blood glucose control in patients with type 2 diabetes mellitus, which can stabilize blood glucose for a long time at a normal level, reduce the incidence of adverse reactions, and improve the quality of life.

上海市長(zhǎng)寧區(qū)天山中醫(yī)醫(yī)院特色專科項(xiàng)目（2017TSZK-02）