目的 系統(tǒng)評價潤燥止癢膠囊聯(lián)用組胺H1受體拮抗劑治療老年皮膚瘙癢癥的臨床療效和安全性，為臨床推廣提供理論依據(jù)。方法 計算機檢索PubMed、Medline、中國生物醫(yī)學文獻數(shù)據(jù)庫（CBM）、中國學術(shù)期刊全文數(shù)據(jù)庫（CNKI）、維普中文科技期刊數(shù)據(jù)庫（VIP）、萬方數(shù)據(jù)庫，收集潤燥止癢膠囊聯(lián)用組胺H1受體拮抗劑與單用組胺H1受體拮抗劑治療老年皮膚瘙癢癥臨床隨機對照研究，采用RevMan 5.2軟件進行Meta分析。結(jié)果 共納入18項研究，2 003例患者。Meta分析結(jié)果顯示，與單用組胺H1受體拮抗劑，潤燥止癢膠囊聯(lián)用組胺H1受體拮抗劑能顯著提高的臨床有效率[RR=1.45，95% CI （1.36，1.54），P<0.01]，降低瘙癢程度評分[MD=-2.83，95% CI （-3.51，-2.15），P<0.01]、瘙癢持續(xù)時間[MD=-2.14，95% CI （-2.49，-1.79），P<0.01]、瘙癢發(fā)作頻率[MD=-2.39，95% CI （-2.81，-1.96），P<0.01]、瘙癢面積[MD=-1.60，95% CI （-1.94，-1.26），P<0.01]和繼發(fā)皮損評分[MD=-1.87，95% CI （-2.48，-1.27），P<0.01]和ADR發(fā)生率[RR=0.67，95% CI （0.52，0.88），P<0.01]。結(jié)論 潤燥止癢膠囊聯(lián)用組胺H1受體拮抗劑治療老年皮膚瘙癢癥的臨床療效優(yōu)于單用組胺H1受體拮抗劑。

Objective To systematically review the efficacy and safety of Runzao Zhiyang Capsule combined with Histamine H1 receptor antagonists in treatment of senile skin pruritus, to provide theoretical basis for clinical popularization.Methods Databases including PubMed, Medline, CNKI, VIP and WanFang Data were searched to collect randomized controlled trials (RCTs) about Runzao Zhiyang Capsule combined with Histamine H1 receptor antagonists vs Histamine H1 receptor antagonists alone in treatment of senile skin pruritus. Then Meta-analysis was conducted by RevMan 5.2 software.Results Total of 18 RCTs, 2003 patients were included. Meta-analysis showed that, compared to histamine H1 receptor antagonists alone, Runzao Zhiyang Capsule combined with histamine H1 receptor antagonists could improved clinical effective rate[RR=1.45, 95% CI(1.36, 1.54), P< 0.01], lower the degree of itching score[MD=-2.83, 95% CI(-3.51, -2.15), P< 0.01], duration of itching[MD=-2.14, 95% CI(-2.49, -1.79), P< 0.01], itching frequency[MD=-2.39, 95% CI(-2.81, -1.96), P< 0.01], itching area[MD=-1.60, 95% CI(-1.94, -1.26), P< 0.01], secondary skin lesions[MD=-1.87, 95% CI(-2.48, -1.27), P< 0.01] and rate of ADR[RR=0.67, 95% CI(0.52, 0.88), P< 0.01].Conclusion Current evidence shows that the clinical curative effect of Runzao Zhiyang Capsule combined with histamine H1 receptor antagonists in treatment of senile skin pruritus much better than histamine H1 receptor antagonists alone.

黃石市醫(yī)藥衛(wèi)生科研指導(dǎo)項目[黃衛(wèi)生計生通（2016）-270-14]