雷公藤甲素是從中藥雷公藤中提取的一種具有多種生物活性的天然產(chǎn)物，是雷公藤片、雷公藤多甙片等制劑的主要有效成分，臨床多用于抗炎及免疫抑制。藥理研究表明雷公藤甲素還具有廣譜、高效的抗腫瘤活性，作用機(jī)制涉及誘導(dǎo)細(xì)胞凋亡、阻滯細(xì)胞周期、逆轉(zhuǎn)腫瘤細(xì)胞多藥耐藥等多個(gè)方面。綜述了雷公藤甲素對(duì)消化系統(tǒng)、生殖系統(tǒng)、血液系統(tǒng)、呼吸系統(tǒng)腫瘤的抗腫瘤作用及相關(guān)機(jī)制的研究進(jìn)展，為加速其抗腫瘤新藥研發(fā)提供理論依據(jù)。

Triptolide, extracted from Chinese herb Tripterygium wilfordii, is a natural product with multiple biological activities, which is the main effective component in preparations of T. wilfordii tablets and T. wilfordii polyglycoside tablets used for anti-inflammatory and immunosuppression in clinic. Pharmacological studies show that triptolide has a broad spectrum and high efficient antitumor activity. The mechanism of action involves inducing apoptosis, blocking cell cycle and reversing multidrug-resistance of tumor cells. This review summarizes the research progress of antitumor activities and related mechanisms of triptolide in the digestive system, reproductive system, hematological system, respiratory system, so as to provide a theoretical basis for speeding up the development of new antitumor drugs.

浙江中醫(yī)藥大學(xué)校級(jí)科研基金項(xiàng)目（2016ZG18）