目的 系統(tǒng)評價5-HTR2A 102T>C基因多態(tài)性與抗精神病藥物療效的相關(guān)性。方法 計算機檢索Web of Science、PubMed、中國學術(shù)期刊全文數(shù)據(jù)庫（CNKI）、萬方數(shù)據(jù)庫、維普數(shù)據(jù)庫中研究5-HTR2A 102T>C基因多態(tài)性與抗精神病藥物療效的研究，檢索年限從建庫至2017年5月2日。按納入與排除標準篩選文獻、提取資料并評價納入研究的方法學質(zhì)量后，采用Stata 12.0軟件進行Meta分析。結(jié)果 共納入10項研究，Meta-分析結(jié)果表明，5-HTR2A 102T>C基因多態(tài)性與抗精神病藥物療效在等位基因模型、共顯性基因模型、顯性基因模型中均無統(tǒng)計學意義（P>0.05）：等位基因模型OR=1.16，95% CI（1.00~1.36）；共顯性基因（TT vs CC）模型OR=1.23，95% CI（0.91~1.65）；共顯性基因（TT vs TC）模型OR=0.90，95% CI（0.68~1.19）；顯性基因模型OR=1.04，95% CI（0.80~1.34）；而隱性基因模型和超顯性基因模型具有統(tǒng)計學意義（P<0.05）：隱性基因模型OR=1.37，95% CI（1.09~1.72）；超顯性基因模型OR=0.78，95% CI（0.62~0.96）。結(jié)論 5-HTR2A 102T>C基因多態(tài)性與抗精神病藥物療效有關(guān)聯(lián)性。

Objective To evaluate the correlation between the clinical efficacy of antipsychotics and 5-HTR2A gene with 102T>C point mutation. Methods The research data from the database of Web of Science, PubMed, CNKI, Wangfang, VIP were searched from the initial date to May 2, 2017 to collecte the published studies about the 5-HTR2A 102T>C polymorphism on the effects of antipsychotics. According to the inclusion and exclusion criteria, the studies were screened, the data were extracted, and methodological quality of the included studies was evaluated. Then Meta-analysis was conducted using Stata 12.0 software. Results A total of 10 studies were included. There was no significant association between 5-HTR2A gene with 102T>C point mutation and the clinical efficacy of antipsychotics in allele gene model, codominant gene model (TT vs CC), codominant gene model (TT vs TC), and dominant gene model (P>0.05):allele gene model, OR=1.16, 95% CI (1.00-1.36); codominant gene model (TT vs CC), OR=1.23, 95% CI (0.91-1.65); codominant gene model (TT vs TC), OR=0.90, 95% CI (0.68-1.19); dominant gene model, OR=1.04, 95% CI (0.80-1.34); However, there was statistical significance in allogene gene model and super-dominant gene model (P<0.05):recessive gene model, OR=1.37, 95% CI (1.09-1.72); super-dominant gene model, OR=0.78, 95% CI (0.62-0.96). Conclusion 5-HTR2A gene with 102T>C point variant has correlation with the clinical efficacy of antipsychotics.

國家自然科學基金（31500281）