阿折地平作為第3代二氫吡啶類鈣拮抗劑，不僅顯示出獨特的降壓優(yōu)勢，還具有減慢心率、抗動脈粥樣硬化、心腎保護、改善胰島素耐受、降低尿酸、減輕肝硬化等藥理作用，具有較高的臨床應用價值。查閱國內外相關文獻，綜述阿折地平的結構特征、藥動學和臨床研究進展，以期為臨床合理用藥及深入研究提供依據。

Azelnidipine as one of the third generation dihydropyridine type calcium channel blockers has high clinical value, it not only shows the unique advantage of antihypertension, but also shows the pharmacological action of heart rate slowing, anti-atherosclerosis, cardiorenal protection, insulin resistance improving, uric acid lowering, hepatic fibrosis alleviating, and so on. This article reviews its structure characteristics, pharmacokinetic and clinical research progresses in the related literatures published at home and abroad, with view to providing a basis for Azelnidipine on clinical rational drug use and deep exploration.

成都醫(yī)學院第一附屬醫(yī)院院級課題項目（CYFY15DL-01）