[關(guān)鍵詞]
[摘要]
為了了解與掌握網(wǎng)絡(luò)毒理學(xué)研究方法及其在中藥毒性成分預(yù)測(cè)中的應(yīng)用;簡(jiǎn)介網(wǎng)絡(luò)毒理學(xué)的概念,分析了網(wǎng)絡(luò)毒理學(xué)的研究思路,總結(jié)了相關(guān)毒性預(yù)測(cè)工具與軟件,概述了毒性預(yù)測(cè)的方法與研究思路,重點(diǎn)綜述了網(wǎng)絡(luò)毒理學(xué)在中藥肝毒性、腎毒性成分、心臟毒性成分與急性毒性成分預(yù)測(cè)中的具體應(yīng)用;隨著現(xiàn)代計(jì)算機(jī)技術(shù)的發(fā)展,網(wǎng)絡(luò)毒理學(xué)已經(jīng)廣泛應(yīng)用于中醫(yī)藥相關(guān)領(lǐng)域,尤其在中藥毒性成分預(yù)測(cè)中,更是發(fā)揮著重要的作用;隨著中醫(yī)藥的現(xiàn)代化,人們更深刻的認(rèn)識(shí)了中藥的毒性成分,迫切需要用現(xiàn)代技術(shù)方法對(duì)中藥毒性進(jìn)行預(yù)測(cè)與評(píng)價(jià),為進(jìn)一步認(rèn)識(shí)和發(fā)展網(wǎng)絡(luò)毒理學(xué)及其在中藥毒性成分預(yù)測(cè)中的應(yīng)用提供了參考依據(jù)。
[Key word]
[Abstract]
In order to understand and master the research methods of network toxicology and its application in the prediction of Chinese traditional Chinese medicine toxicology. In this paper, we mainly explore the concept of network of toxicology, and analyze the network toxicology research train of thought, summarize the related toxicity prediction tools and software, the toxicity prediction method as well as the research train of thought, the key network toxicology were reviewed in application of prediction of traditional Chinese medicine liver toxicity and kidney toxicity, heart toxicity component and forecasting acute toxicity composition. With the development of modern computer technology, network toxicology has been widely used in the related fields of traditional Chinese medicine, especially in the prediction of the toxicity of traditional Chinese medicine, which plays an important role. With the modernization of traditional Chinese medicine, people are more deeply aware of the toxicity of traditional Chinese medicine, and it is urgent to predict and evaluate the toxicity of traditional Chinese medicine with modern techniques. The study of this paper provides a reference for further understanding and development of network toxicology and its application in predicting the toxicity of Chinese medicine.
[中圖分類(lèi)號(hào)]
[基金項(xiàng)目]