+CD4+、CD3+CD8+細(xì)胞比例顯著上升(P<0.05、0.01);BALF中的IL-10、IL-1β、IL-6、IL-4、TNF-α的水平明顯降低(P<0.05、0.01);且對(duì)IL-1β及TNF-α的下調(diào)作用優(yōu)于陽(yáng)性對(duì)照藥;脾臟指數(shù)明顯升高(P<0.05、0.01)。結(jié)論 還貝止咳方對(duì)細(xì)菌性大鼠肺炎模型具有一定的治療作用,主要通過(guò)調(diào)節(jié)大鼠的免疫功能,減輕炎性反應(yīng)發(fā)揮作用。;Objective To observe the effect of Huanbei Zhike Recipe on thymus, spleen index, inflammatory cells, and inflammatory cytokines in lung heat model rats induced by Streptococcus pneumoniae. Methods SD young rats were randomly divided into control group, model group, Cefuroxime Axetil Tablets group, children's lung hot cough and asthma granule group and Huanbeizhike recipe lower, middle and high dose group. The rat lung heat model was established by the nasal drip of Streptococcus pneumoniae. The body temperature of the rats was monitored before and after modeling to evaluate the rat model of pulmonary hyperthermia. The flow cytometry and whole blood analyzer were used to detect the inflammatory cells in rat whole blood. The secretion levels of IL-10, IL-1β, IL-6, IL-4, TNF-α and IgE in rat lung lavage fluid (BALF) were detected by enzyme-linked immunosorbent assay. The spleen and thymus were stripped completely, and spleen index and thymus index were detected. Results The body temperature of model group was significantly increased (P<0.01), indicating successful modeling. Compared with the model group, the body temperature, leukocyte, neutrophil number and Th/Ts ratio in the whole blood of Huanbeizhike recipe low, medium and high dose groups were significantly decreased and CD3+CD4+ and CD3+CD8+ increased significantly (P<0.05 and 0.01). The levels of IL-10, IL-1β, IL-6, IL-4 and TNF-α of BALF were significantly decreased (P<0.05 and 0.01) of Huanbeizhike recipe, and the down-regulation effect of IL-1β and TNF-α was better than that of positive control. The spleen index of Huanbeizhike recipe was significantly increased (P<0.05 and 0.01). Conclusion Huanbeizhike Recipe has a certain therapeutic effect on the bacterial rat pneumonia model, mainly through the regulation of the immune function of rats to reduce the inflammatory effect."/>

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首頁(yè) > 過(guò)刊瀏覽>2018年第41卷第5期 >2018,41(5):788-793. DOI:10.7501/j.issn.1674-6376.2018.05.e012
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還貝止咳方對(duì)肺炎鏈球菌致大鼠肺熱的治療作用

Effect of huanbeizhike recipe on lung heat model induced by Streptococcus pneumoniae in rats

發(fā)布日期:2018-05-09
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