2均大于50。結(jié)論 在4種不同的溶出介質(zhì)中,自制片與參比制劑體外溶出一致。;Objective To prepare gliclazide tablets and to evaluate its consistency of dissolution tests. Methods The single factor experiments were applied to investigating several factors on the dissolution, such as the amount of the adhesive, the amount of lubricant, the particle size and tablet hardness.708-DS Dissolution Tester was used to conduct the dissolution tests which were carried on four different dissolution media. Then the similar factor (f2) was adopted to evaluate the similarity of dissolution between the original drug and generic drug. Results Three batches of homemade-tablets were eluted more than 85% within 15 min in phosphate buffered saline (pH7.4), and the f2 values were greater than 50 in water, pH 1.2 hydrochloric acid solution and pH 6.0 phosphate solution. Conclusion In four different dissolution media, self-made tablets and reference formulations in vitro dissolution consistent."/>

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首頁 > 過刊瀏覽>2018年第41卷第5期 >2018,41(5):821-827. DOI:10.7501/j.issn.1674-6376.2018.05.e017
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格列齊特片的制備工藝和溶出一致性評(píng)價(jià)

Preparation of gliclazide tablets and consistency study of their dissolubility

發(fā)布日期:2018-05-09
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