目的 探討曲美他嗪聯(lián)合阿托伐他汀對冠心病患者心功能及炎癥因子的影響。方法 選取冠心病患者79例，隨機(jī)分為對照組（38例）和觀察組（41例），2組均給予冠心病常規(guī)治療，對照組加用阿托伐他汀，觀察組在對照組基礎(chǔ)上加用曲美他嗪，兩組患者療程均為3個月。比較兩組患者治療前后左室后壁厚度（LVPWd），左室射血分?jǐn)?shù)（LVEF）、左室舒張末期內(nèi)徑（LVEDd）、6 min步行距離（6MWD）、C反應(yīng)蛋白（hsCRP）、白介素-6（IL-6）、血清腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，兩組的LVPWd、LVEDd、LVEF、6MWD較治療前明顯改善，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組改善程度顯著比對照組好，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組的hsCRP、IL-6、TNF-α均較治療前顯著降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組降低程度比對照組顯著，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 曲美他嗪聯(lián)合阿托伐他汀可有效改善冠心病患者心功能，降低炎癥反應(yīng)。

Objective To investigate the effects of trimetazidine combined with atorvastatin on the cardiac function,inflammatory factors in patients with coronary heart disease (CHD). Methods Choose 79 patients with CHD, who were randomly divided into control group (38 cases) and observation group (41 cases). Both groups were taken routine treatment. The patients in control group were added atorvastatin, while those in observation group were added trimetazidine combined with atorvastatin. All patients were treated for three months. LVPWd, LVEF, LVEDd, 6MWD, hsCRP, IL-6 and TNF-α were compared between control group and observation group before and after treatment. Results After treatment, LVPWd, LVEDd, LVEF, 6MWD of both groups were obviously improved compared with before treatment, and the observation group improved significantly better than the control group (P<0.05). After treatment, hsCRP, IL-6 and TNF-α of both groups were obviously improved compared with before treatment, and the observation group improved significantly better than the control group (P<0.05). Conclusions Trimetazidine combined with atorvastatin can effectively improve heart function, reduce inflammatory reactions in patients with CHD.