0.05)。結(jié)論 聯(lián)用沙利度胺在類風(fēng)濕關(guān)節(jié)炎的治療中有積極作用。;Objective To systematically review the efficiency and safety of thalidomide combined with other drugs in the treatment of rheumatoid arthritis. Methods The randomized controlled trials (RCTs) about thalidomide treating rheumatoid arthritis were retrieved in the database of PubMed, Medline Web of science, CNKI, VIP, CBM, and Wanfang Data from the date of database foundation to August 2017. Meta-analysis was performed with state14.0 software. Results A total of 15 RCTs involving 1 246 patients were finally included; Meta-analysis results showed that, the effect of thalidomide combined with control was superior to control alone in the effective rate (OR=2.71, 95% CI=1.87-3.93, P<0.05), joint swelling number (OR=1.68, 95% CI=0.99-2.37, P<0.05), joint tenderness number(OR=2.22, 95% CI=1.31-3.14, P<0.05), and erythrocyte sedimentation rate (OR=12.93, 95% CI=10.26-15.60, P<0.05). There was no significant difference in the occurrence of adverse events between the thalidomide group and control group (OR=0.93, 95% CI=0.66-1.32, P>0.05). Conclusion Thalidomide combined with other drugs has a positive effect on the treatment of rheumatoid arthritis."/>