[關鍵詞]
[摘要]
腫瘤多藥耐藥(MDR)是導致腫瘤化療失敗的主要原因之一。腫瘤MDR的機制有多種,其中外排型轉運體的過表達是導致MDR的主要機制,因此研究外排型轉運體介導的腫瘤MDR機制和發(fā)現(xiàn)可以逆轉腫瘤MDR的抑制劑成為國內外研究的熱點。就目前研究的3種三磷酸腺苷結合盒轉運體:P-糖蛋白、多藥耐藥相關蛋白、乳腺癌耐藥蛋白介導的MDR及逆轉MDR的機制進行綜述,以期為提高腫瘤治療療效提供依據(jù)。
[Key word]
[Abstract]
Multidrug resistance (MDR) is one of the major causes of tumor chemotherapy failure. There are many mechanisms of MDR in tumors, in which the overexpression of efflux transporters is the main mechanism leading to MDR. Therefore, it has become a research hotspot at home and abroad to study the mechanisms of tumor MDR mediated by efflux transporter and to find out inhibitors which can reverse the tumor MDR. The current studies on the three kinds of adenosine triphosphate binding cassette transporters:P-glycoprotein, multidrug resistance-associated protein, breast cancer resistance protein-mediated MDR, and reversal mechanism of MDR were reviewed in order to provide basis for improving the therapeutic efficacy of cancer.
[中圖分類號]
[基金項目]
國家自然科學基金資助項目(81473280)