[關(guān)鍵詞]
[摘要]
腫瘤多藥耐藥(MDR)是導(dǎo)致腫瘤化療失敗的主要原因之一。腫瘤MDR的機(jī)制有多種,其中外排型轉(zhuǎn)運(yùn)體的過表達(dá)是導(dǎo)致MDR的主要機(jī)制,因此研究外排型轉(zhuǎn)運(yùn)體介導(dǎo)的腫瘤MDR機(jī)制和發(fā)現(xiàn)可以逆轉(zhuǎn)腫瘤MDR的抑制劑成為國(guó)內(nèi)外研究的熱點(diǎn)。就目前研究的3種三磷酸腺苷結(jié)合盒轉(zhuǎn)運(yùn)體:P-糖蛋白、多藥耐藥相關(guān)蛋白、乳腺癌耐藥蛋白介導(dǎo)的MDR及逆轉(zhuǎn)MDR的機(jī)制進(jìn)行綜述,以期為提高腫瘤治療療效提供依據(jù)。
[Key word]
[Abstract]
Multidrug resistance (MDR) is one of the major causes of tumor chemotherapy failure. There are many mechanisms of MDR in tumors, in which the overexpression of efflux transporters is the main mechanism leading to MDR. Therefore, it has become a research hotspot at home and abroad to study the mechanisms of tumor MDR mediated by efflux transporter and to find out inhibitors which can reverse the tumor MDR. The current studies on the three kinds of adenosine triphosphate binding cassette transporters:P-glycoprotein, multidrug resistance-associated protein, breast cancer resistance protein-mediated MDR, and reversal mechanism of MDR were reviewed in order to provide basis for improving the therapeutic efficacy of cancer.
[中圖分類號(hào)]
[基金項(xiàng)目]
國(guó)家自然科學(xué)基金資助項(xiàng)目(81473280)