目的 分析并探討碳青霉烯類雙聯(lián)治療銅綠假單胞菌的臨床效果，并對其安全性進行評估，進而為臨床治療方案的選擇提供依據(jù)。方法 選取2016年5月—2017年5月江油市九〇三醫(yī)院收治的銅綠假單胞菌肺炎患者120例，根據(jù)隨機數(shù)字表法將其分為對照組和研究組，各60例。對照組患者給予頭孢哌酮鈉舒巴坦鈉2 g，靜脈滴注，每天3次；研究組給予碳青霉烯類雙聯(lián)法治療，靜脈滴注亞胺培南-西司他丁鈉1 g，以及美羅培南500 mg，每天3次。連續(xù)治療15 d為1個療程。比較兩組患者的治療效果，觀察并詳細記錄患者的兩組患者細菌的清除情況，采用問卷調(diào)查的形式對患者的社會功能、軀體功能、角色功能以及認知功能進行評分。結(jié)果 研究組的治療總有效率為91.6%，對照組總有效率為78.3%，研究組有效率明顯高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05)。治療前，兩組患者的生活質(zhì)量評分無明顯區(qū)別；治療后，研究組患者的生活質(zhì)量評分明顯高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，研究組細菌清除率（80.0%）明顯高于對照組（66.7%），差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 使用碳青霉烯類雙聯(lián)法對銅綠假單胞菌肺炎患者進行治療，可有效地清除患者體內(nèi)的細菌，提高患者的生活質(zhì)量，該治療方法臨床效果顯著，相比較其他的治療方法更有應(yīng)用價值，癥狀改善明顯，且安全性高，值得臨床推廣。

Objective To analyze and explore the clinical effect of carbapenem combined therapy on Pseudomonas aeruginosa, and to evaluate its safety and provide the basis for the selection of clinical treatment regimen. Methods A total of 120 patients with Pseudomonas aeruginosa pneumonia treated in our hospital from May 2016 to May 2017 were randomly divided into control group and study group, with 60 cases in each group. The patients of the control group were treated with routine treatment, while patients of the study group were treated with carbapenem combined therapy. The therapeutic effects of the two groups were compared. Results The total effective rate of the study group was 78.3%, and 91.6% in the control group. The effective rate of the study group was significantly higher than that of the control group (P<0.05). Before treatment, there was no significant difference in the quality of life scores between the two groups. After treatment, the quality of life of the study group was significantly higher than that of the control group (P<0.05). After treatment, the bacterial clearance rate in the study group was significantly higher than that of the control group. Conclusion The treatment of patients with Pseudomonas aeruginosa pneumonia by carbapenem combined method can effectively remove the bacteria and improve the quality of life of the patients. The clinical effect of carbapenem combined therapy is significant, compared with other methods of treatment, which has application value, can improve symptoms significantly, with high security, is worthy of clinical promotion.