環(huán)烯醚萜類化合物是存在于多種中藥材里的一類重要成分，具有多種生物活性。從吸收、分布、代謝、排泄4個方面對常見的環(huán)烯醚萜類化合物（梔子苷、胡黃連苷、獐牙菜苦苷等）在動物體內(nèi)的藥動學(xué)研究進(jìn)行整理和綜述，發(fā)現(xiàn)這類化合物具有在體內(nèi)快速吸收，在腎、肝等組織臟器中廣泛分布，經(jīng)水解和葡萄糖醛酸化等多種代謝過程后迅速排泄出體外的藥動學(xué)特點(diǎn)，為提高該類化合物的生物利用度以及新藥研發(fā)提供參考。

Ridoids are important compounds of Chinese medicinal herbs with various biological activities. Pharmacokinetics research of typical iridoid compounds such as geniposide, picroside and swertiamain in recent years was reviewed based on four aspects of absorption, distribution, metabolism and excretion in animals. These compounds are rapidly absorbed, widely distributed in organs such as kidney and liver, metabolized through processes including hydrolysis and glucuronization, and then quickly excreted. This review provides reference for bioavailability improvement and drug development of iridoids.

國家“重大新藥創(chuàng)制”科技重大專項(xiàng)（2013ZX09602202）