隱丹參酮是從中藥丹參里提取的一種天然活性成分，具有多種藥理作用，不僅能預防和治療缺血性疾病、冠狀動脈疾病和阿爾茨海默氏癥，還具有良好的抗腫瘤活性。它通過抑制腫瘤細胞增殖、誘導腫瘤細胞凋亡、抑制腫瘤轉移和侵襲、抗新血管生成及調控活性氧水平等途徑發(fā)揮抗腫瘤作用。對近年來研究的隱丹參酮的抗腫瘤活性和作用機制進行綜述。

Cryptotanshinone is a natural compound isolated from the plant Salvia miltiorrhiza Bunge. It has many pharmacological effects, including prevention and treatment of acute ischemic stroke, coronary artery disease, Alzheimer's disease and anti-cancer. Recent studies have been shown that cryptotanshinone also could inhibit proliferation and induce apoptosis of cancer cells, inhibit migration, invasion and angiogenesis of tumor cells, and regulating the levels of reactive oxygen species to exert antitumor pharmacological activity. This study will review the antitumor pharmacological activity and the mechanism of cryptotanshinone.

黑龍江省科學基金資助項目（LC2015036）；黑龍江省大學生創(chuàng)新創(chuàng)業(yè)訓練計劃項目（201710223001）