近年來中藥及其制劑的安全用藥備受國(guó)內(nèi)外學(xué)者的關(guān)注。綜述了甘草酸苷注射液、復(fù)方甘草口服液、復(fù)方甘草片等甘草類制劑不良反應(yīng)的研究進(jìn)展，從其引發(fā)的內(nèi)分泌、心血管、神經(jīng)、生殖、消化、免疫等多個(gè)系統(tǒng)的不良反應(yīng)進(jìn)行總結(jié)闡述，其中主要涉及到的作用機(jī)制包括雌激素樣作用、糖皮質(zhì)激素樣作用、鹽皮質(zhì)激素樣作用等，希望能夠指導(dǎo)甘草及其制劑在臨床上的合理使用。

In recent years, the safety of traditional Chinese medicine and its preparations have attracted much attention. The research progress of the adverse reactions of glycyrrhizin injection, compound licorice oral liquid, compound licorice tablets and other licorice preparations is reviewed. From the licorice-induced endocrine, cardiovascular, neurological, reproductive, digestive, immune and other systemic adverse reactions is summarized. The main mechanisms involved are estrogen-like effects, glucocorticoid-like effects, and mineralocorticoid-like effects, hope to guide the correct use of licorice and its preparations in clinical practice.

國(guó)家自然科學(xué)基金資助項(xiàng)目（81573825）