目的 探討檢驗(yàn)危急值在嚴(yán)重藥品不良反應(yīng)（SADR）監(jiān)測(cè)中的應(yīng)用價(jià)值。方法 回顧性分析2016年1月-2017年6月我院收集到的基于檢驗(yàn)危急值及傳統(tǒng)監(jiān)測(cè)模式的SADR報(bào)告表，對(duì)兩種監(jiān)測(cè)模式從患者性別與年齡、不良反應(yīng)特點(diǎn)、科室分布及潛伏期、因果關(guān)系及轉(zhuǎn)歸方面，分別進(jìn)行歸類整理并進(jìn)行統(tǒng)計(jì)分析。結(jié)果 福州市長(zhǎng)樂(lè)區(qū)醫(yī)院共收集SADR 395例，65歲以上年齡段的患者引起SADR最多，占54.44%；基于檢驗(yàn)危急值的有251例，占63.54%，與傳統(tǒng)監(jiān)測(cè)模式比較差異顯著（P<0.01）；科室分布方面，居前3位的科室分別為消化內(nèi)科、內(nèi)分泌科、神經(jīng)內(nèi)科，兩種監(jiān)測(cè)模式無(wú)顯著差異；檢驗(yàn)危急值監(jiān)測(cè)模式居前3位的不良反應(yīng)分別為肝功能異常、低血糖、腎功能損害，傳統(tǒng)監(jiān)測(cè)模式居前3位的分別為胃腸系統(tǒng)損害、全身性損害、代謝和營(yíng)養(yǎng)障礙，二者互為補(bǔ)充；潛伏期評(píng)價(jià)中，最短的為3 min，最長(zhǎng)的為7年；關(guān)聯(lián)性評(píng)價(jià)中，"很可能"46例，占11.65%，"可能"349例，占88.35%；轉(zhuǎn)歸情況方面，痊愈74份，占18.73%，好轉(zhuǎn)283份，占71.65%。結(jié)論 本研究為藥品安全性信息的更新及補(bǔ)充提供重要數(shù)據(jù)，檢驗(yàn)危急值在SADR監(jiān)測(cè)工作中具有重要意義，可有效提高監(jiān)測(cè)工作效率和能力。

Objective To investigate the application value of critical value in monitoring serious adverse drug reactions (SADR). Methods A report of SADR, which was collected by Fuzhou Changle District Hospital from January 2016 to June 2017, was reviewed based on the critical value of inspection and the traditional monitoring model. The two types of monitoring models were classified and analyzed from the gender, age, the characteristics of adverse reactions, the distribution and incubation period of the department, the correlation, and the outcome. Results A total of 395 cases of SADR were collected in Fuzhou Changle District Hospital, which was based on the critical value of the 251 cases, accounting for 63.54%; Compared with the traditional monitoring mode has a significant difference (P<0.01). Patients aged 65 and above had the most SADR, accounting for 54.44%. In the area of department distribution, the top three departments were the department of digestive medicine, the department of endocrinology, and the department of neurology, which of the two monitoring modes had no significant differences. The top three adverse reactions in the critical value monitoring model were liver dysfunction, hypoglycemia, and renal function damage respectively. The top three in the traditional monitoring model were gastrointestinal system damage, systemic damage, metabolism and nutritional disorders, and the two were supplemented by each other. The shortest incubation period was 3 min and the longest was 7 years. In correlation assessment, 46 cases were likely to be involved, accounting for 11.65%, and 349 cases were possible, accounting for 88.35%. In terms of outcome, 74 cases recovered, accounting for 18.73%, and 283 cases improved, accounting for 71.65%. Conclusion This study provides important data for updating and supplementation of drug safety information. The critical value of test is of great significance in the monitoring of SADR. By analyzing the critical value of the test, we can effectively improve the efficiency and ability of monitoring SADR.