腫瘤細(xì)胞的代謝重排是腫瘤發(fā)生發(fā)展過程中的一個(gè)重要特征，主要表現(xiàn)為糖酵解、谷氨酰胺代謝及生物合成活動(dòng)的增強(qiáng)。鑒于腫瘤代謝重排在腫瘤發(fā)展中的關(guān)鍵作用，靶向腫瘤細(xì)胞代謝已成為國際上抗腫瘤藥物研發(fā)的熱點(diǎn)之一。腫瘤微血管新生是腫瘤進(jìn)展的另一個(gè)重要特點(diǎn)，與腫瘤血管內(nèi)皮細(xì)胞的代謝轉(zhuǎn)變密切相關(guān)，其為腫瘤細(xì)胞的代謝活動(dòng)提供物質(zhì)支持。該文討論了腫瘤細(xì)胞與內(nèi)皮細(xì)胞代謝中異常的代謝變化及探討了兩者的關(guān)系，并綜述了靶向前述代謝變化的藥物研發(fā)進(jìn)展。

The reprogramming of cellular metabolism is one of the hallmarks of cancer,which is featured as enhanced glycolysis, glutamine metabolism and other biosynthetic activities. Given its crucial role in tumor development, targeting tumor cell metabolism has become one of the hotspots in the research and development of antitumor drugs. Angiogenesis, a process related to a metabolic shift in endothelial cells, is another hallmark of cancer and supports the metabolic activities in tumor cells. In this article, the abnormal metabolic pathways in tumor cells and tumor endothelial cells were discussed and their relevance was further explored. The advance in therapeutic medicine targeting the metabolic pathways above was also summarized.

國家自然科學(xué)基金項(xiàng)目（81573496，81773989）