目的 探討尿毒清顆粒聯(lián)合羥苯磺酸鈣治療慢性腎衰竭的療效及對結(jié)締組織生長因子（CTGF）、骨形態(tài)發(fā)生蛋白-7（BMP-7）的影響。方法 采用回顧性總結(jié)研究方法，2016年4月—2018年1月選擇在安陽市第六人民醫(yī)院進(jìn)行維持性血液透析的慢性腎衰竭患者92例，根據(jù)治療方法的不同分為觀察組與對照組各46例，對照組給予羥苯磺酸鈣治療，觀察組在對照組治療的基礎(chǔ)上給予尿毒清顆粒治療，兩組都治療觀察3個月，記錄CTGF、BMP-7變化情況。結(jié)果 觀察組的總有效率為97.8%，高于對照組的87.0%，對比差異有統(tǒng)計學(xué)意義（P<0.05）。治療后兩組血清血尿素氮（BUN）與肌酐（Scr）值都顯著高于治療前（P<0.05），治療后觀察組顯著低于對照組（P<0.05）。治療后兩組血清CTGF值顯著降低、BMP-7值顯著升高，對比差異有統(tǒng)計學(xué)意義（P<0.05），治療后觀察組與對照組對比差異也有統(tǒng)計學(xué)意義（P<0.05）。治療后觀察組的人際關(guān)系敏感、抑郁、焦慮、精神病性、敵對性、恐怖、偏執(zhí)、軀體化、強(qiáng)迫癥狀等評分低于對照組，對比差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 尿毒清顆粒聯(lián)合羥苯磺酸鈣治療慢性腎衰竭能提高治療效果，調(diào)節(jié)CTGF和BMP-7分泌平衡，改善患者的腎腎功能，提高患者的生活質(zhì)量。

Objective To investigate the effects of Niaoduqing granule combined with calcium dobesilate on chronic renal failure and its effects on CTGF and BMP-7. Methods From April 2016 to January 2018, 92 patients with chronic renal failure in maintenance hemodialysis were selected in our hospital and were divided into the observation group and the control group of 46 cases in each groups accorded to the different treatment methods. The control group were given calcium hydroxybenzene sulfonate treatment, and the observation group were given Niao Du Qing granule combined with calcium dobesilate treatment, the two groups were treated for 3 months, and the changes of CTGF and BMP-7 were recorded. Results The total effective rate of the observation group were 97.8%, which was higher than that of the control group of 87%, and compared the difference were statistically significant (P < 0.05). After treatment, the serum BUN and Scr values of the two groups were significantly higher than those before treatment (P < 0.05), and the observation group were significantly lower than that of the control group (P < 0.05). After treatment, the value of CTGF in the two groups were decreased significantly and the value of BMP-7 were increased significantly, the difference compared between the observation group and the control group after treatment were also statistically significantly (P < 0.05). After treatment, the scores of interpersonal sensitivity, depression, anxiety, psychosis, hostility, horror, paranoia, somatization and compulsion were lower in the observation group than in the control group (P < 0.05). Conclusion Niao Du Qing granule combined with calcium dobesilate can improve the therapeutic effect, regulate the balance of CTGF and BMP-7, improve the renal function of the patients and improve the quality of life of the patients.