果蠅作為廣泛應(yīng)用于衰老研究領(lǐng)域的模式生物，與其他衰老的動物模型相比較，果蠅衰老模型具有生長周期短，繁殖力強(qiáng)，雌雄易分辨，實(shí)驗(yàn)操作簡單的優(yōu)點(diǎn)，能夠保證足夠的數(shù)量以及足夠的空間進(jìn)行實(shí)驗(yàn)，同時(shí)還有基因保守性高等特點(diǎn)，因此是一種常用的衰老模式生物，近些年其在加快抗衰老藥物的篩選速度和衰老的機(jī)制研究等方面顯示出潛在的應(yīng)用價(jià)值。對果蠅衰老模型的建立方法、給藥方式、藥效學(xué)評價(jià)、抗衰老通路及果蠅在部分抗衰老中藥中的應(yīng)用5個方面進(jìn)行綜述，分別介紹了5種果蠅衰老模型，不同的給藥方式以及行為學(xué)，生化指標(biāo)和代謝組學(xué)方面的研究，分析了模式生物果蠅與衰老相關(guān)的信號通路和機(jī)制，列舉了的部分抗衰老中藥在衰老模式生物果蠅中的應(yīng)用，為今后衰老機(jī)制的研究、抗衰老中藥物和保健品的開發(fā)等提供理論依據(jù)和實(shí)驗(yàn)參考。

Drosophila is a model organism widely used in the field of aging research. Compared with other aging animal models, Drosophila aging model has easy feeding, short growth cycle, strong fertility, easy to distinguish between male and female, simple experimental operation, and sufficient to ensure sufficient The quantity and sufficient space for experiments, as well as the high degree of gene conservation, are a common aging model organism. In recent years, it has shown potential in accelerating the screening speed of anti-aging drugs and the mechanism of aging. Value. In this paper, the establishment methods, mode of administration, pharmacodynamic evaluation, anti-aging pathway and application of Drosophila in some anti-aging Chinese medicines were reviewed. Five fruit fly aging models were introduced. The mode of administration, as well as behavioral, biochemical and metabolomic studies, analyzed the signaling pathways and mechanisms associated with aging in Drosophila, and listed some of the anti-aging Chinese medicines used in aging model organisms. Provide theoretical basis and experimental reference for the research of aging mechanism, the development of anti-aging drugs and health products.

山西省重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（201703D321023-3）；山西省科技基礎(chǔ)條件平臺建設(shè)項(xiàng)目（2014091022）。