目的 探討熊去氧膽酸膠囊聯(lián)合水飛薊賓治療酒精性肝硬化的臨床療效。方法 選取2016年1月-2018月1月在濮陽市人民醫(yī)院收治的酒精性肝硬化患者100例，采用隨機(jī)數(shù)字表法分為對照組和觀察組，每組各50例，對照組患者僅給予水飛薊賓，觀察組患者給予熊去氧膽酸膠囊聯(lián)合水飛薊賓，比較兩組患者治療前后低密度脂蛋白膽固醇（LDL-C）、高密度脂蛋白膽固醇（HDL-C）、總膽固醇（TC）、三酰甘油（TG）、天冬氨酸氨基轉(zhuǎn)移酶（AST）、丙氨酸氨基轉(zhuǎn)移酶（ALT）和γ-谷氨酰轉(zhuǎn)肽酶（GGT）、總膽紅素（Tbil）、直接膽紅素（Dbil）和間接膽紅素（Ibil）的水平并比較治療期間不良反應(yīng)的發(fā)生率。結(jié)果 治療后，兩組患者的GGT、ALT及AST水平均顯著降低，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；與對照組相比，觀察組患者的GGT、ALT及AST水平均顯著降低，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組患者的Tbil、Dbil及Ibil水平均顯著降低，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）；與對照組相比，觀察組患者的Tbil、Dbil及Ibil水平均顯著降低，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，觀察組患者的LDL-C、TC及TG水平均顯著降低，而HDL-C顯著升高，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；與對照組相比，觀察組患者的LDL-C、TC及TG水平均顯著降低，而HDL-C顯著升高，差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組患者的不良反應(yīng)發(fā)生率（8.00%）顯著低于對照組（24.00%），差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 熊去氧膽酸膠囊聯(lián)合水飛薊賓治療酒精性肝硬化的臨床效果較好，能夠有效改善患者的血脂水平并提高肝功能。

Objective To investigate the clinical effect of ursodesoxycholic acid and silybin in the treatment of alcoholic cirrhosis. Methods 100 cases alcoholic cirrhosis patients were collected from January 2016 to January 2018 in People's Hospital of Puyang, according to the random number method divided into control group and observation group, each group has 50 cases, the control group was given silybin, the observation group was given ursodesoxycholic acid and silybin, compared with the level of LDL-C, HDL-C, TC, TG, AST, ALT and GGT, and the incidence of adverse reaction during the treatment. Results Before treatment, compared with the γ -glutamyl endopeptidase, ALT and ASTbetween the control and observation group, the difference was not statistically significant. After treatment, compared with the control group, the γ -glutamyl endopeptidase, ALT and AST both significantly decreased of the observation group, the difference was statistically significant (P<0.05). After treatment, compared with the control group, the LDL-C, TC, TG, Tbil, Dbil and Ibil both significantly decreased of the observation group, the HDL-C significantly increased, the difference was statistically significant (P<0.05). The incidence of the adverse drug reaction of the observation group is 4 cases (8.00%), the incidence of the adverse drug reaction of the control group is 12 cases (24.00%), the differences was statistically significant (P<0.05).Conclusion Ursodesoxycholic acid and silybin has good effect in the treatment of alcoholic cirrhosis, can improve the serum lipid level and liver function.