目的 探討鹽酸右美托咪定注射液對腹腔鏡結(jié)直腸癌根治術(shù)患者術(shù)后轉(zhuǎn)歸的影響。方法 選取2015年6月-2017年6月眉山市人民醫(yī)院行腹腔鏡結(jié)直腸癌根治術(shù)患者160例作為研究對象，按隨機數(shù)字表法將患者分為對照組和觀察組，每組各80例。兩組患者均采用全身麻醉，觀察組在此基礎(chǔ)上于麻醉誘導(dǎo)前10 min采用微量注射泵靜脈輸注鹽酸右美托咪定注射液0.5 μg/（kg·h），10 min內(nèi)泵完，再以0.5 μg/（kg·h）維持至手術(shù)結(jié)束。對照組按照相同的輸注方式給予相同劑量的生理鹽水。比較兩組術(shù)后復(fù)蘇指標(biāo)、不同時間點血流動力學(xué)指標(biāo)、鎮(zhèn)痛及鎮(zhèn)靜效果分?jǐn)?shù)。結(jié)果 術(shù)后兩組患者睜眼時間、呼吸恢復(fù)時間、拔管時間差異無統(tǒng)計學(xué)意義；觀察組躁動評分顯著低于對照組（P<0.05）。治療后，T₀-T₃時刻兩組患者平均動脈壓（MAP）、心率（HR）水平先降低再升高最終又降低，且T₁、T₂時刻觀察組明顯低于對照組（P<0.05）。術(shù)后觀察組患者Ramsay鎮(zhèn)靜評分、靜息及咳嗽VAS評分均明顯降低于對照組（P<0.05）。結(jié)論 鹽酸右美托咪定注射液可顯著減少腹腔鏡結(jié)直腸癌根治術(shù)的應(yīng)激反應(yīng)，改善血流動力學(xué)，鎮(zhèn)靜鎮(zhèn)痛效果顯著，減少復(fù)蘇期躁動的發(fā)生，且未增加不良反應(yīng)，有利于患者術(shù)后轉(zhuǎn)歸。

Objective To investigate the effect of Dexmedetomidine Hydrochloride Injection on postoperative outcomes in patients undergoing laparoscopic radical resection of colorectal cancer.Methods Patients (160 cases) with laparoscopic radical resection of colorectal cancer in Meishan People's Hospital from June 2015 to June 2017 were divided into control and observation groups according to the random number table method, each group had 80 cases. Patients in two groups were given general anesthesia. Observation group received intravenous infusion of Dexmedetomidine Hydrochloride Injection 0.5 ug/(kg·h) with a microinjection pump in 10 min before induction of anesthesia, then maintained at 0.5 ug/(kg·h) until the end of operation. The control group was given the same dose of saline by the same infusion method. The various indexes of anabiosis, the indexes of haemodynamics at different time points, and the analgesia and sedation scores were compared in two groups. Results There was no statistically significant difference between the two groups in the time of eye opening, respiratory recovery and extubation, the restlessness score in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the MAP and HR levels in two groups from T₀ to T₃ were decreased, and then increased, and decreased finally, and at T₁ and T₂, the observation group was significantly lower than those in the control group (P<0.05). The Ramsay sedation score, resting and cough VAS scores in the observation group were significantly lower than those in the control group (P<0.05).Conclusions Dexmedetomidine Hydrochloride Injection can significantly reduce the stress response, improve hemodynamics, sedative and analgesic effect is remarkable, and reduce the occurrence of restlessness in the recovery period without increasing adverse reactions, which is conducive to the postoperative outcome of patients.