1mg/mL、聯(lián)用中藥注射劑、超劑量用藥和年齡<3歲是兒童使用喜炎平注射液發(fā)生AS的獨(dú)立危險(xiǎn)因素。結(jié)論 臨床實(shí)踐中應(yīng)重點(diǎn)關(guān)注有獨(dú)立危險(xiǎn)因素的患者,以保證兒童患者使用喜炎平注射液臨床安全用藥。;Objective To investigate risk factors of anaphylactic shock(AS)caused by Xiyanping Injection in children, and provide a reference for clinical safety medication. Methods Retrospectively analyze the clinical data of 680 children who were treated with Xiyanping Injection in Jingmen First People's Hospital, Jingmen Second People's Hospital and Jingmen Petrochemical Hospital from January of 2016 to October of 2018. According to AS diagnostic criteria, they were divided into AS group (128 patients) and non-AS group (552 patients). Univariate (χ2 test) and multiple factors (Logistic regression) were used to select risk factors that related to AS. Results The incidence of AS in children Xiyanping Injection accounted for 18.82% of ADR. And 49.22% AS occurred within 30 minutes of the first medication. Most of patients gradually improved their allergy symptoms after drug withdrawal, oxygen inhalation, and anti-allergic interventions. Univariate analysis showed that the age, body mass index (BMI), history of allergies, admission to the ICU, number of combinations, combined Chinese medicine injections, overdose medication, infusion concentration, and pretreatment of patient associated with AS, and multiple factors analysis showed that pretreatment (infusion tube), creatinine clearance<30 mL/min, admission to ICU, infusion concentration>1 mg/mL, combination of traditional Chinese medicine injection, overdose medication and age<3 years were independent risk factors. Conclusion Clinical practice should focus on patients with independent risk factors to ensure clinical safety use of Xiyanping Injection."/>