糖皮質(zhì)激素（GC）具有強(qiáng)大的抗炎作用，是臨床上使用最為廣泛的免疫抑制劑，然而部分患者在使用激素治療一段時(shí)間后會(huì)出現(xiàn)激素抵抗性。巨噬細(xì)胞移動(dòng)抑制因子（MIF）是截至目前被認(rèn)為唯一能負(fù)向調(diào)節(jié)GC抗炎作用的細(xì)胞因子，但MIF在糖皮質(zhì)激素抵抗機(jī)制中扮演什么樣的角色，尚未完全闡明。對(duì)MIF參與抵抗糖皮質(zhì)激素抗炎作用的機(jī)制進(jìn)行綜述。

With strong anti-inflammatory effect, glucocorticoid (GC) is clinically the most widely used immunosuppressant. However, some patients shows steroid resistance and do not achieve an effective response with GC treatment. Macrophage migration inhibitory factor is considered as the only factor which could negatively regulate the anti-inflammatory effect of GC, but the underlying mechanism is still not clear. The paper aims to review the role of macrophage migration inhibitory factor in resistance mechanism of glucocorticoid in inflammatory diseases.