糖皮質(zhì)激素（GC）具有強大的抗炎作用，是臨床上使用最為廣泛的免疫抑制劑，然而部分患者在使用激素治療一段時間后會出現(xiàn)激素抵抗性。巨噬細胞移動抑制因子（MIF）是截至目前被認為唯一能負向調(diào)節(jié)GC抗炎作用的細胞因子，但MIF在糖皮質(zhì)激素抵抗機制中扮演什么樣的角色，尚未完全闡明。對MIF參與抵抗糖皮質(zhì)激素抗炎作用的機制進行綜述。

With strong anti-inflammatory effect, glucocorticoid (GC) is clinically the most widely used immunosuppressant. However, some patients shows steroid resistance and do not achieve an effective response with GC treatment. Macrophage migration inhibitory factor is considered as the only factor which could negatively regulate the anti-inflammatory effect of GC, but the underlying mechanism is still not clear. The paper aims to review the role of macrophage migration inhibitory factor in resistance mechanism of glucocorticoid in inflammatory diseases.