鹽酸小檗堿（berberine）是從黃連中提取的一種天然的異喹啉類生物堿。小檗堿具有多種藥理作用，包括抗病原微生物、抗炎、抗腫瘤、心臟保護(hù)、降血糖、調(diào)節(jié)脂質(zhì)代謝以及免疫抑制等。近10年來(lái)，國(guó)內(nèi)外學(xué)者對(duì)小檗堿調(diào)脂機(jī)制進(jìn)行了廣泛的研究。從調(diào)節(jié)血漿脂質(zhì)合成、促進(jìn)脂質(zhì)分解等方面對(duì)小檗堿改善血脂機(jī)制加以綜述，為其進(jìn)一步開發(fā)和研究提供參考。

Berberine is a natural isoquinoline alkaloid extracted from Coptis chinensis. Berberine has several pharmacological activities, including disease-resistant microorganisms, anti-inflammatory, anti-tumor, heart protection, hypoglycemia, regulation of lipid metabolism and immunomodulatory properties. In recent ten years,the domestic and foreign scholars have extensively studied on Lipid Regulating of berberine. In this paper, the mechanism of improving blood lipid by berberine was reviewed from the aspects of regulating plasma lipid synthesis and promoting lipid decomposition.