目的 探討疏風(fēng)解毒膠囊免疫調(diào)節(jié)作用機(jī)制。方法 采用肺炎鏈球菌致肺炎大鼠模型，觀察疏風(fēng)解毒膠囊給藥后對(duì)淋巴細(xì)胞分類，細(xì)胞因子白細(xì)胞介素-1α（IL-1α）、IL-1β、IL-2、IL-4、IL-6、IL-10、腫瘤壞死因子-α（TNF-α）、α干擾素（IFN-α）、γ干擾素（IFN-γ）水平，免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）水平，胸腺、脾臟、肺臟質(zhì)量的影響。結(jié)果 疏風(fēng)解毒膠囊能顯著降低模型大鼠外周血B淋巴細(xì)胞比例、CD8⁺比例，降低血清IL-1α、IL-1β、IL-2、IL-10、TNF-α、IFN-α、IFN-γ、IgM、IgG水平，降低肺炎大鼠胸腺、脾臟、肺臟質(zhì)量，升高外周血CD4⁺/CD8⁺及NK細(xì)胞比例。結(jié)論 疏風(fēng)解毒膠囊有顯著的免疫調(diào)節(jié)作用，其通過(guò)降低B淋巴細(xì)胞、CD8⁺比例及IL-1α、IL-1β、IL-2、IL-10、TNF-α、IFN-α、IFN-γ、IgM、IgG水平，降低肺炎大鼠胸腺、脾臟、肺臟質(zhì)量，升高CD4⁺/CD8⁺及NK細(xì)胞比例對(duì)肺炎模型大鼠有顯著的治療作用。

Objective To explore the immunoregulation of Shufeng Jiedu Capsule (SJC) and its mechanism. Methods Using the Streptococcus pneumoniae (SP)-induced pneumonia rats model to study the immunoregulation of SJC, collecting peripheral blood and serum to measure the factors related to immune response such as lymphocyte classification, interleukin-1α (IL-1α), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor (TNF-α), interferon-α (IFN-α), interferon-γ (IFN-γ), immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), and the weight of thymus, spleen and lung. Results SJC can significantly decrease B cell (%) and CD8⁺(%) in peripheral blood, decrease the levels of IL-1α, IL-1β, IL-2, IL-10, TNF-α, IFN-α, IFN-γ, IgM, and IgG in serum, reduce the weight of thymus, spleen, and lung. It also increased the content of CD4⁺/CD8⁺ and NK cell (%) in peripheral blood. Conclusion SJC has significant immunomodulatory effect and shows significant therapeutic effect on pneumonia model rats by decreasing the content of B cell (%), CD8⁺(%), IL-1α, IL-1β, IL-2, IL-10, TNF-α, IFN-α, IFN-γ, IgM, and IgG, reducing the weight of thymus, spleen and lung, and increasing the content of CD4⁺/CD8⁺ and NK cell (%) in peripheral blood.

國(guó)家中藥標(biāo)準(zhǔn)化專項(xiàng)資助（ZYBZH-C-AH-02）；國(guó)家自然科學(xué)基金資助項(xiàng)目（81430096）；國(guó)家自然科學(xué)基金資助項(xiàng)目（81703802）