目的 對疏風(fēng)解毒膠囊進(jìn)行拆方研究，研究清熱解毒組分、解表組分及其配伍組合分別對急性肺炎模型大鼠血清細(xì)胞因子水平的影響，從而分析疏風(fēng)解毒膠囊配伍合理性。方法 制備肺炎鏈球菌致肺炎大鼠模型，分為對照組、模型組、頭孢氨芐組、疏風(fēng)解毒膠囊全方組（全方組）、疏風(fēng)解毒膠囊解表組（解表組）、疏風(fēng)解毒膠囊清熱解毒組（清熱解毒組），連續(xù)給藥6 d，檢測各組大鼠血清中白細(xì)胞介素-1α（IL-1α）、IL-1β、IL-2、IL-4、IL-6、IL-10、腫瘤壞死因子-α（TNF-α）、α干擾素（IFN-α）、IFN-γ水平，評價(jià)組方配伍的合理性。結(jié)果 疏風(fēng)解毒膠囊全方、解表組分、清熱解毒組分均能顯著降低IL-1α、IL-1β、IL-2、IL-4、IL-10水平，全方組大鼠在IL-1β水平上Q值>1；疏風(fēng)解毒膠囊全方、解表組分、清熱解毒組分均能顯著降低TNF-α、IFN-γ水平，疏風(fēng)解毒膠囊全方、解表組分能顯著降低IFN-α水平；全方組大鼠在TNF-α、IFN-α水平這2個(gè)指標(biāo)上Q值>1。結(jié)論 疏風(fēng)解毒膠囊有顯著的調(diào)節(jié)免疫功能的作用，解表組分和清熱解毒組分有顯著的協(xié)同作用。

Objective In order to study the decomposed on separated complex prescription of Shufeng Jiedu Capsule (SJC) and analyze the compatibility rationality, the effects of heat-clearing and toxin-removing component, exterior-releasing component and their combination on serum cytokines content of rats with acute pneumonia were studied. Methods The pneumonia model of rats induced by Streptococcus pneumoniae was used, wich were divided into control group, model group, cephalexin group, SJC whole prescription group (whole prescription group), SJC exterior-releasing group (exterior-releasing group), SJC heat-clearing and toxinremoving group (heat-clearing and toxin-removing group). After administration for 6 days, content of IL-1α, IL-1β, IL-2, IL-4, IL-10, TNF-α, IFN-α, and IFN-γ was tested to evaluate the compatibility rationality. Results The content of IL-1α, IL-1β, IL-2, IL-4 and IL-10 was significantly reduced by the whole prescription, the exterior-releasing component and the heat-clearing and toxinremoving components of SJC. The Q value of rats in the whole prescription group was beyond 1 on the content of IL-1β. The content of TNF-α and IFN-γ was significantly reduced by the whole prescription, the exterior-releasing components and the heatclearing and toxin-removing component of SJC. The content of IFN-α was significantly reduced by the whole prescription, the relieving exterior component of SJC. The Q values of rats in the whole prescription group were beyond 1 on the content of TNF-α and IFN-α. Conclusion SJC has significant immunomodulatory effect and has a significant therapeutic effect on Streptococcus pneumoniae infection in rats. The exterior-releasing component and the heat-clearing and toxin-removing component have significant synergistic effects.

國家中藥標(biāo)準(zhǔn)化專項(xiàng)資助（ZYBZH-C-AH-02）；國家自然科學(xué)基金資助項(xiàng)目（81430096）；國家自然科學(xué)基金資助項(xiàng)目（81703802）