目的 研究參芪降糖顆粒聯(lián)合鹽酸二甲雙胍片對(duì)妊娠期糖尿病患者妊娠結(jié)局和胰島β細(xì)胞功能的影響。方法 選擇2015年1月-2017年12月西安市中醫(yī)醫(yī)院的95例妊娠期糖尿病患者，隨機(jī)將患者分為對(duì)照組（48例）和觀察組（47例）。對(duì)照組于餐后口服鹽酸二甲雙胍片，0.25 g/次，3次/d；觀察組在對(duì)照組基礎(chǔ)上沖服參芪降糖顆粒，3 g/次，3次/d。比較兩組患者的妊娠結(jié)局，治療前后的餐后2 h血糖、空腹血糖、胰島β細(xì)胞功能以及血脂水平。結(jié)果 觀察組的剖宮產(chǎn)率以及胎盤早剝、產(chǎn)后出血、HPLLP綜合征等并發(fā)癥的發(fā)生率均明顯低于對(duì)照組（P<0.05）。觀察組的新生兒窒息、胎兒窘迫、巨大兒、胎兒早產(chǎn)和圍產(chǎn)兒死亡發(fā)生率均明顯低于對(duì)照組（P<0.05）。治療后，兩組的餐后2 h血糖以及空腹血糖值均明顯降低，HOMA-β明顯升高（P<0.05），且觀察組餐后2 h血糖以及空腹血糖值均明顯低于對(duì)照組，HOMA-β明顯高于對(duì)照組（P<0.05）。治療后，兩組三酰甘油（TG）、總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）水平均顯著降低，低密度脂蛋白膽固醇（LDL-C）顯著升高，同組治療前后比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05），且觀察組血脂水平明顯優(yōu)于對(duì)照組，兩組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 參芪降糖顆粒聯(lián)合鹽酸二甲雙胍片可以有效改善妊娠期糖尿病患者的妊娠結(jié)局以及胰島β細(xì)胞功能，降低血糖和血脂水平，具有較高的臨床參考應(yīng)用價(jià)值。

Objective To investigate the clinical effect of Shenqi Jiangtang Granules combined with Metformin Hydrochloride Tablets on pregnancy outcome and islet beta cell function in patients with gestational diabetes. Methods A total of 95 cases of patients with gestational diabetes in Xi'an Traditional Chinese Medicine Hospital from January 2015 to December 2017 were randomly divided into control group (48 cases) and observation group (47 cases). Patients in the control group were po administered with Metformin Hydrochloride Tablets after meals, 0.25 g/time, three times daily. Patients in the observation group were po administered with Shenqi Jiangtang Granules on the basis of control group, 3 g/time, three times daily. The pregnancy outcomes, postprandial 2 h blood glucose, fasting blood glucose, islet beta cell function, and blood lipid levels of two groups before and after treatment were compared. Results The rate of cesarean section rate and the incidence of complications such as placental abruption, postpartum hemorrhage and HPLLP syndrome were significantly lower than those of the control group (P<0.05). The incidence of neonatal asphyxia, fetal distress, fetal distress, fetal macrosomia, fetal preterm birth, and perinatal mortality in the observation group were significantly lower than those of the control group (P<0.05). After treatment, 2 h blood glucose and fasting blood glucose were significantly decreased, HOMA-β was significantly increased (P<0.05). And 2 h blood glucose and fasting blood glucose in the observation group were significantly lower than those in the control group, HOMA-β was significantly higher than those in the control group (P<0.05). After treatment, the levels of TG, TC, and LDL-C in two groups were significantly decreased, but the HDLC was increased (P<0.05). And the levels of blood lipid in the observation group were significantly better than those in the control group (P<0.05). Conclusion Shenqi Jiangtang Granules combined with Metformin Hydrochloride Tablets can effectively improve pregnancy outcome and pancreatic beta cell function, reduce blood sugar and blood lipid level in patients with gestational diabetes mellitus, and has a high clinical reference value.