目的 研究丹紅注射液聯(lián)合尿毒清顆粒對高血壓中早期慢性腎衰竭患者的尿蛋白及腎功能的影響。方法 選擇2015年5月-2018年5月在寶雞市中醫(yī)醫(yī)院進行診治的83例高血壓早中期慢性腎衰竭患者為研究對象，隨機分為觀察組（43例）對照組（40例）。對照組口服尿毒清顆粒治療，5 g/次，4次/d；觀察組在對照組基礎(chǔ)上靜脈滴注丹紅注射液40 mL+5%葡萄糖注射液200 mL，1次/d。兩組均治療3周。比較兩組治療前后的臨床療效、腎功能指標和實驗室指標的變化。結(jié)果 治療后觀察組的總有效率為88.37%，顯著高于對照組的65.00%，兩組比較差異具有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者的血肌酐（Scr）、尿素氮（BUN）和24 h尿蛋白量與治療前比均降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組各項腎功能指標水平顯著低于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。治療后，兩組患者的β2微球蛋白（β2-MG）、血清胱抑素C（Cys-C）、內(nèi)皮素1（ET-1）和超敏C反應(yīng)蛋白（hs-CRP）水平與治療前比均降低，同組治療前后比較差異有統(tǒng)計學(xué)意義（P<0.05）；且觀察組各項實驗室指標顯著低于對照組，兩組比較差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 丹紅注射液聯(lián)合尿毒清顆粒治療高血壓早中期慢性腎衰竭療效顯著，能有效改善患者的腎功能狀態(tài)和炎癥狀態(tài)，可在臨床推廣應(yīng)用。

Objective To investigate the effect on urinary protein and renal function in patients of hypertension included earlymiddle stage chronic renal failure by using Danhong Injectioncombined with Niaoduqing Granules. Methods Selected 83 cases of patients with hypertension included early-middle stage chronic renal failure in Traditional Chinese Medical Hospital of Baoji from May 2015 to May 2018 were divided into observation group (43 cases) and control group (40 cases) randomly. The control group were po administered with Niaoduqing Granules, 5 g/time, four times daily. The observation group were iv administered with Danhong Injection, 40 mL added into 5% Glucose Injection 200 mL, once daily. Patients in two groups were treated for 3 weeks. Clinical effects, renal function indexes and laboratory examination indexes were compared. Results After treatment, the total effective rate of the observation group was 88.37%, which was significantly higher than 65.00% in the control group, and there was difference between two groups (P<0.05). After treatment, the levels of Scr, BUN, and 24 h urinary protein in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the renal function indexes in the observation group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of β2-MG, Cys-C, ET-1, and hs-CRP were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And laboratory examination indexes in the observation group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Danhong Injection combined with Niaoduqing Granules in treatment of hypertension included early-middle stage chronic renal failure has a significant effect, can effectively improve the renal function and inflammatory state of patients, and can be popularized in clinical application.