目的 探討還原型谷胱甘肽聯(lián)合注射用鹽酸納洛酮治療新生兒缺氧缺血性腦病的臨床效果。方法 選取2015年6月-2018年6月在安陽市中醫(yī)院就診的60例新生兒缺氧缺血性腦病患兒為研究對象，隨機分為觀察組（30例）和對照組（30例）。對照組給予患兒靜脈滴注注射用鹽酸納洛酮0.02 mg/kg，1次/d。觀察組在對照組基礎上給予患兒還原型谷胱甘肽，20 mg加入20 mL 5%葡萄糖注射液中靜脈滴注，1次/d。兩組均治療14 d。觀察兩組患者的臨床療效，對比兩組臨床癥狀消失時間、神經元特異性烯醇化酶（NSE）水平和新生兒行為神經測定（NBNA）評分以及不良反應發(fā)生情況。結果 與對照組總有效率73.33%比較，觀察組總有效率96.67%顯著升高（P<0.05）。治療后，觀察組肌張力、意識障礙和驚厥消失時間均顯著短于對照組（P<0.05）。治療后，兩組NSE水平均較治療前顯著降低，NBNA評分均較治療前顯著升高（P<0.05）；治療后，觀察組NSE水平和NBNA評分改善顯著優(yōu)于對照組（P<0.05）。兩組不良反應發(fā)生率分別為13.33%、6.67%，兩組比較差異無統(tǒng)計學意義。結論 還原型谷胱甘肽聯(lián)合注射用鹽酸納洛酮治療新生兒缺氧缺血性腦病效果顯著，值得臨床推廣。

Objective To investigate the clinical effect of reduced glutathione combined with Naloxone Hydrochloride for Injection in treatment of neonatal hypoxic ischemic encephalopathy. Methods 60 cases of neonatal hypoxic ischemic encephalopathy in Anyang Hospital of Traditional Chinese Medicine from June 2015 to June 2018 were randomly divided into observation (30 cases) and control group (30 cases). Children in the control group iv administered with Naloxone Hydrochloride for Injection, 0.02 mg/kg, once daily. Children in the observation group were iv administered with reduced glutathione, 20 mg added into 5% Glucose Injection 20 mL, once daily. Children in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, NSE, NBNA score, and adverse reactions in two groups were compared. Results The total effective rate of observation group was 96.67%, which were higher than 73.33% of control group (P<0.05). After treatment, the time of muscle tension, disturbance of consciousness and convulsion disappeared in the observation group were significantly shorter than those in the control group (P<0.05). After treatment, the level of NSE in two group was significantly decreased, but the NBNA score was increased (P<0.05). After treatment, the changes of NSE and NBNA scores in the observation group were significantly better than those in the control group (P<0.05). The incidence of adverse reactions in two groups were 13.33% and 6.67%, there was no significant difference between two groups. Conclusion Reduced glutathione combined with Naloxone Hydrochloride for Injection in treatment of neonatal hypoxic ischemic encephalopathy has good effect, which is worthy of clinical promotion.