氧化苦參堿多種途徑給藥（靜脈滴注、肌肉注射或口服）治療慢性乙型肝炎都有較好的療效。氧化苦參堿的臨床療效與劑量和用藥時間存在一定的相關(guān)性，其中與用藥時間的關(guān)系更為密切。注射給藥的療效快于口服，因此治療開始時可注射給藥，隨后改為口服給藥以持續(xù)提高療效。氧化苦參堿除直接的抗病毒、抗炎、肝臟保護作用外，還可通過提高患者的免疫調(diào)節(jié)作用，間接增強機體清除和抑制病毒的能力，這可能是其治療乙型肝炎療效持續(xù)穩(wěn)定的作用機制。

Oxymatrine has clinical efficacy for the treatment of chronic hepatitis B by multiple routes of administration (intravenous drip, intramuscular injection or oral administration). The clinical efficacy of oxymatrine has a certain correlativity with dosage and administering time, the correlation with administering time is more intimate than to dosage. Clinical efficacy of injection is faster occurrence than oral, for this reason, oxymatrine treatment keep on a steady increase in the clinical efficacy. Except direct effects of anti-virus, anti-inflammation, and hepatoprotection, oxymatrine indirectly promotes ability of body to inhibit and eliminate virus by increasing immunoregulation of patient. This may be the effective mechanism of continued steady efficacy of oxymatrine for the treatment of hepatitis B.