肺部吸入制劑在治療肺炎、哮喘、慢性阻塞性肺?。–OPD）等肺部疾病中的應(yīng)用廣泛。肺部吸入制劑主要包括吸入氣霧劑、干粉吸入劑、吸入噴霧劑和吸入溶液，其體外評(píng)價(jià)方法主要包括遞送劑量及遞送劑量均一性，空氣動(dòng)力學(xué)粒徑分布，噴霧模式和噴霧形態(tài)；體內(nèi)評(píng)價(jià)方法主要包括藥動(dòng)學(xué)研究與放射性核素成像。就肺部吸入制劑的體內(nèi)外評(píng)價(jià)方法的研究進(jìn)展進(jìn)行綜述。

Pulmonary Inhalation preparations are widely used in the treatment of lung diseases such as pneumonia, asthma, and chronic obstructive pulmonary disease (COPD). Pulmonary inhalation preparationsmainly include metered dose inhaler, dry powder inhalation, sprays and inhalation solution. The in vitro evaluation characteristic detection mainly includes delivered dosage, delivery dose uniformity, aerodynamic particle size distribution, spray pattern and plume geometry.The in vivo evaluation methods mainly include pharmacokinetic studies and radionuclide imaging techniques. This review discusses the in vitro and in vivo evaluation methods of pulmonary inhalation preparations.