目的 觀察艾普拉唑腸溶片聯(lián)合阿莫西林膠囊治療消化性潰瘍的療效。方法 選擇2016年1月-2019年1月江蘇省海門市人民醫(yī)院收治的98例消化性潰瘍患者，隨機(jī)分為兩組，每組各49例。對(duì)照組服用阿莫西林膠囊治療，0.5 g/次，3次/d，于餐后30 min服用。觀察組在對(duì)照組的基礎(chǔ)上艾普拉唑腸溶片，10 mg/次，1次/d。兩組均連續(xù)治療4周。記錄患者的臨床治療效果、HP根除率、潰瘍愈合時(shí)間以及HP根除時(shí)間。并檢測血清胃泌素基因和胃泌素表達(dá)水平，血清白細(xì)胞介素-17（IL-17）和一氧化氮（NO）水平。結(jié)果 治療后，觀察組的總有效率為93.88%，顯著高于對(duì)照組的75.51%（P<0.05）。治療后，觀察組的HP根除率高于對(duì)照組，潰瘍愈合時(shí)間和HP根除時(shí)間短于對(duì)照組（P<0.05）。兩組治療后的血清胃泌素基因以及胃泌素表達(dá)水平均降低（P<0.05），且觀察組更低（P<0.05）。兩組治療后的血清IL-17和NO水平均降低（P<0.05），且觀察組更低（P<0.05）。結(jié)論 艾普拉唑腸溶片聯(lián)合阿莫西林膠囊治療消化性潰瘍療效顯著，能降低患者的炎癥反應(yīng)及血清胃泌素基因和胃泌素表達(dá)水平，值得臨床推廣。

Objective To observe the effect of Ilaprazole Enteric-coated Tablets combined with Amoxicillin Capsules in treatment of peptic ulcer. Methods Selected 98 cases of patients with peptic ulcer who were treated in Haimen People's Hospital from January 2016 to January 2019 were divided into two groups randomly, and each group had 49 cases. The control group was treated with Amoxicillin Capsules 30 min after meal, 0.5 g/time, three times daily. While the observation group was treated with Ilaprazole Enteric-coated Tablets on the basis of control group, 10 mg/time, once daily. Patients in two groups were treated for 4 weeks. The clinical therapeutic effect, HP eradication rate, ulcer healing time and HP eradication time were recorded. Serum gastrin gene and gastrin expression levels, serum IL-17 and NO levels were detected. Results After treatment, the total effective rate of the observation group was 93.88%, which was significantly higher than 75.51% in the control group (P<0.05). After treatment, the HP eradication rate in the observation group was significantly higher than that in the control group, and the ulcer healing time and HP eradication time in the observation group were significantly shorter than those in the control group (P<0.05). After treatment, the levels of serum gastrin gene and gastrin expression in two groups were significantly decreased (P<0.05), and the levels of gastrin expression in the observation group was significantly lower (P<0.05). After treatment, the levels of serum IL-17 and NO in two groups were significantly decreased after treatment (P<0.05), and the observation group was significantly lower (P<0.05). Conclusion Ilaprazole Enteric-coated Tablets combined withAmoxicillin Capsules in treatment of peptic ulcer has a significant effect. It can reduce the inflammatory reaction, and the levels of gastrin gene and gastrin expression. It is worthy of clinical promotion.

江蘇省藥學(xué)會(huì)-奧賽康臨床藥學(xué)基金科研項(xiàng)目（201519）