目的 探討細(xì)菌溶解產(chǎn)物膠囊聯(lián)合匹多莫德顆粒對(duì)兒童咳嗽變異性哮喘患兒免疫功能的影響。方法 選取2015年8月-2018年8月在榆林市第二醫(yī)院就診的82例兒童咳嗽變異性哮喘患兒，按照患者入院先后順序編號(hào)，采用奇偶數(shù)法分為觀察組（n=41）和對(duì)照組（n=41）。對(duì)照組給予匹多莫德顆粒，0.4 g/次，3次/d。觀察組在對(duì)照組基礎(chǔ)上給予細(xì)菌溶解產(chǎn)物膠囊7 mg/次，1次/d。均治療21 d。對(duì)比兩組臨床療效、肺功能、萊塞斯特咳嗽生命質(zhì)量問(wèn)卷（LCQ）評(píng)分及免疫功能指標(biāo)情況。結(jié)果 治療后，觀察組總有效率90.24%，顯著高于對(duì)照組的65.85%（P<0.05）。治療后，兩組一秒用力呼氣容積（FEV1）、呼氣峰流速（PEF）和FEV1/FVC均較治療前顯著升高（P<0.05），且觀察組肺功能明顯高于對(duì)照組（P<0.05）。治療后兩組LCQ評(píng)分（生理、心理、社會(huì)和總分）均較治療前顯著升高（P<0.05）；且觀察組LCQ評(píng)分明顯高于對(duì)照組（P<0.05）。治療后，兩組白介素-4（IL-4）、腫瘤壞死因子-α（TNF-α）和血清免疫球蛋白E（IgE）均顯著低于治療前（P<0.05）；且觀察組IL-4、TNF-α和IgE均顯著低于對(duì)照組（P<0.05）。結(jié)論 細(xì)菌溶解產(chǎn)物膠囊聯(lián)合匹多莫德顆?？捎行Ц纳苾和人宰儺愋韵純悍喂δ芎蜕钯|(zhì)量，提高免疫功能，值得臨床推廣。

Objective To investigate the effect of Bacterial Lysates Capsules combined with Pidotimod Granules on immune function in children with cough variant asthma. Methods Children (82 cases) with cough variant asthma who were treated in The Yulin Second Hospital from August 2015 to August 2018, they were numbered in order of admission and divided into observation group (n=41) and control group (n=41) by odd and even number method. Children in the control group were given Pidotimod Granules, 0.4 g/time, three times daily. Children in the observation group were given Bacterial Lysates Capsules on the basis of control group, 7 mg/time, once daily. Children in two groups were treated for 21 d. The clinical effects, lung function, LCQ score, and immune function of two groups were compared. Results After treatment, the total effective rate of the observation group was 90.24%, which was significantly higher than 65.85% of the control group (P<0.05). After treatment, the levels of FEV1, PEF and FEV1/FVC in two groups were significantly increased (P<0.05), and the lung function in the observation group were significantly higher than those in the control group (P<0.05). After treatment, physiological, psychological, social and total scores in two groups were significantly increased (P<0.05), and the LCQ scores in the observation group were significantly higher than those in the control group (P<0.05). After treatment, IL-4, TNF-α and IgE were significantly lower than those before treatment (P<0.05), and IL-4, TNF-α and IgE were significantly lower than those in the control group (P<0.05). Conclusion Bacterial Lysates Capsules combined with Pidotimod Granules can effectively improve pulmonary function and quality of life in children with cough variant asthma, and improve immune function, which is worthy of clinical promotion.

陜西省衛(wèi)生廳小兒疾病研究（2008K14-05）