目的 研究苦碟子注射液聯(lián)合依帕司他對糖尿病周圍神經(jīng)病變的療效。方法 選擇2017年1月-2018年12月喀什地區(qū)第二人民醫(yī)院收治的100例糖尿病周圍神經(jīng)病變患者為研究對象，隨機(jī)分為兩組。對照組口服依帕司他片，50 mg/次，3次/d。觀察組在對照組基礎(chǔ)上聯(lián)用苦碟子注射液，將40 mL苦碟子注射液加入250 mL生理鹽水中靜脈滴注，1次/d。兩組均治療14 d。比較兩組患者的臨床療效，同時(shí)比較兩組治療前后的脛神經(jīng)和正中神經(jīng)的傳導(dǎo)速度。結(jié)果 治療后，觀察組的有效率為86.00%，明顯高于對照組的70.00%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。治療后，兩組脛神經(jīng)的傳導(dǎo)速度明顯加快，波幅明顯升高，潛伏期明顯縮短，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組的脛神經(jīng)傳導(dǎo)速度明顯優(yōu)于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組治療后的正中神經(jīng)的潛伏期明顯縮短，波幅明顯升高，傳導(dǎo)速度明顯加快，同組治療前后比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；且觀察組的正中神經(jīng)傳導(dǎo)速度明顯優(yōu)于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 苦碟子注射液聯(lián)合依帕司他對糖尿病周圍神經(jīng)病變的療效較為理想，可明顯改善神經(jīng)傳導(dǎo)速度。

Objective To study the effect of Kudiezi Injection combined with epalrestat on diabetic peripheral neuropathy and nerve conduction velocity. Methods Selected 100 cases of patients with diabetic peripheral neuropathy in Kashgar Pregecture Second People's Hospital from January 2017 to December 2018 were divided into two groups randomly. Patients in the control group was given Epalrestat Tablets orally, 50 mg/time, three times daily. While patients in the observation group were iv administered with Kudiezi Injection, 40 mL added into 250 mL normal saline, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the conduction velocities of tibial and median nerves were compared between two groups. Results After treatment, the effective rate of the observation group was 86.00%, which was significantly higher than 70.00% in the control group (P<0.05). After treatment, the conduction velocity of tibial nerve in two groups were significantly accelerated, the amplitude were significantly increased, the latency were significantly shortened (P<0.05), and the conduction velocity of tibial nerve in the observation group was significantly better than that in the control group (P<0.05). After treatment, the latency of median nerve in two groups were significantly shortened, the amplitude were significantly increased, the conduction velocity were significantly accelerated (P<0.05), and the conduction velocity of median nerve in the observation group was significantly better than that in the control group (P<0.05). Conclusion Kudiezi Injection combined with epalrestat is effective in treating diabetic peripheral neuropathy, and can significantly improve nerve conduction velocity.

國家自然科學(xué)基金-地區(qū)科學(xué)基金項(xiàng)目（82560112）；喀什地區(qū)第二人民醫(yī)院院內(nèi)科研項(xiàng)目（KSEY201707）