目的 探討注射用丹參多酚酸對(duì)腦卒中患者血流變、肢體與神經(jīng)功能的影響。方法 選取唐山市人民醫(yī)院2017年2月-2019年2月診治的腦卒中患者146例，采用隨機(jī)數(shù)字表法分為兩組（各73例），對(duì)照組患者實(shí)施常規(guī)治療，觀察者患者常規(guī)治療基礎(chǔ)上聯(lián)用注射用丹參多酚酸0.13 g/d靜脈滴注，均連續(xù)治療14 d。于治療前后行血流變、生化指標(biāo)檢測(cè)，并行肢體與神經(jīng)功能評(píng)價(jià)，比較兩組患者的治療效果及安全性。結(jié)果 兩組患者治療后全血高切黏度、全血低切黏度、血漿黏度、血小板聚集率、C反應(yīng)蛋白、D-二聚體、同型半胱氨酸（Hcy）、神經(jīng)元特異性烯醇化酶（NSE）、美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NHISS）評(píng)分較治療前顯著降低（P<0.05），簡(jiǎn)式運(yùn)動(dòng)功能量表（FMA）、日常生活能力（ADL）評(píng)分較治療前顯著增加（P<0.05）。觀察組患者治療后全血高切黏度、全血低切黏度、血漿黏度、血小板聚集率、C反應(yīng)蛋白、D-二聚體、Hcy、NSE、NHISS評(píng)分低于對(duì)照組（P<0.05），F(xiàn)MA評(píng)分、ADL評(píng)分高于對(duì)照組（P<0.05）；觀察組患者總有效率高于對(duì)照組（P<0.05）。兩組患者不良反應(yīng)（心率異常、血壓異常、肝腎功能損害）比較，差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論 注射用丹參多酚酸可改善腦卒中患者的血流變狀況，并提高患者的肢體與神經(jīng)功能。

Objective To investigate the influence of Salvianolic Acids for Injection (SAFI) on hemorrheology, limb and nerve function in stroke patients. Methods 146 stroke patients were selected in Tangshan People's Hospital from December 2016 to December 2018, who were divided into two groups by random number table method. 73 patients received routine treatment as control group, and 73 patients combined with SAFI (0.13 g/d intravenous drip for 14 days) as observation group. Hemorrheology and biochemical indexes were measured before and after treatment. While parallel limb and nerve function were evaluated. Treatment effect and safety were compared between two groups. Results Whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, platelet aggregation rate, C-reactive protein, D-dimer, homocysteine, neuron-specific enolase, and NHISS score were decreased significantly in two groups after treatment (P<0.05). FMA score and ADL score were increased significantly in two groups after treatment (P<0.05). Whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, platelet aggregation rate, C-reactive protein, D-dimer, homocysteine, neuron-specific enolase, and NHISS score in observation group were lower than control group after treatment (P<0.05). FMA score and ADL score in observation group were higher than control group after treatment (P<0.05).Total effective rate in observation group was higher than control group (P<0.05). There were no significant differences in adverse reactions (heart rate abnormality, blood pressure abnormality, liver and kidney dysfunction) between two groups. Conclusion SAFI can improve hemorheological status in stroke patients, which can also improve limb and nerve function.