目的 探討注射用丹參多酚酸治療急性腦梗塞的效果及對(duì)認(rèn)知功能、同型半胱氨酸（Hcy）、神經(jīng)元特異性烯醇化酶（NSE）、S-100β、膠質(zhì)纖維酸性蛋白（GFAP）的影響。方法 選取唐山市人民醫(yī)院2017年10月-2018年10月收治的急性腦梗塞患者162例，采用隨機(jī)數(shù)字表法分為兩組（各81例），對(duì)照組實(shí)施常規(guī)治療，觀察者在常規(guī)治療基礎(chǔ)上聯(lián)用注射用丹參多酚酸100 mg/次，靜脈滴注，1次/d，連續(xù)治療14 d，于治療前后檢測(cè)Hcy、NSE、S-100β和GFAP，并評(píng)定患者認(rèn)知功能、神經(jīng)功能，比較兩組臨床療效及不良反應(yīng)。結(jié)果 兩組患者治療后Hcy、NSE、S-100β、GFAP、美國(guó)國(guó)立衛(wèi)生研究院卒中量表（NHISS）評(píng)分均較治療前降低（P<0.05），簡(jiǎn)易精神狀態(tài)評(píng)價(jià)量表（MMSE）評(píng)分、蒙特利爾認(rèn)知評(píng)估量表（MOCA）評(píng)分較治療前增加（P<0.05）；且觀察組患者治療后Hcy、NSE、S-100β、GFAP、NHISS評(píng)分低于對(duì)照組（P<0.05），治療后MMSE評(píng)分、MOCA評(píng)分高于對(duì)照組（P<0.05）。觀察組患者總有效率高于對(duì)照組（P<0.05）；兩組不良反應(yīng)比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。結(jié)論 注射用丹參多酚酸治療急性腦梗塞的效果顯著，可改善認(rèn)知功能和神經(jīng)功能狀況，并改善Hcy、NSE、S-100β、GFAP等指征。

Objective To investigate the effect of Salvianolic Acids for Injection (SAFI) in treatment for acute cerebral infarction and its influence on cognitive function, homocysteine (Hcy), neuron specific enolase (NSE), S-100β, and glial fibrillary acidic protein (GFAP). Methods A total of 162 patients were selected in Tangshan People's Hospital from October 2017 to October 2018, who were divided into two groups by random number table method (n=81). 81 patients in the observation group received routine treatment as control group. 81 patients combined with SAFI 100 mg/time, intravenous drip, once a day, continuous treatment for 14 days. Hcy, NSE, S-100β, and GFAP were detected before and after treatment, and cognitive function and neurological function were assessed. Clinical efficacy and adverse reactions were compared between two groups. Results After the treatment, Hcy, NSE, S-100β, GFAP, and NHISS score were decreased in two groups (P<0.05). MMSE score and MOCA score were increased in two groups (P<0.05). Hcy, NSE, S-100β, GFAP, and NHISS score in observation group were lower than control group (P<0.05). MMSE score and MOCA score in observation group were higher than control group (P<0.05). Total effective rate in observation group was higher than control group (P<0.05). There were no significant differences in adverse reactions between two groups (P>0.05). Conclusion SAFI has significant effect in treatment for acute cerebral infarction, which can improve cognitive function and neurological function, and improve indicators of Hcy, NSE, S-100β, and GFAP.

河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題（20171288，20181217）