隨著生物技術的發(fā)展，在過去的幾十年里越來越多細菌性聯(lián)合疫苗被批準上市，不僅提高了疫苗覆蓋率和接種率，而且減少疫苗管理上的各種成本，同時也減少了由于多次免疫接種給接種者所帶來的痛苦。就當前細菌性聯(lián)合疫苗發(fā)展現(xiàn)狀以及面臨的挑戰(zhàn)進行綜述，希望對國內細菌性聯(lián)合疫苗的研發(fā)及免疫策略的優(yōu)化提供一定參考。

With the development of biotechnology, more and more bacterial combination vaccines have been licensed in the past few decades. These vaccines not only improve the coverage and immunization rates of vaccine, but also reduce various costs in vaccine management. Furthermore, the pain caused by multiple immunizations to subjects is also reduced. This article reviews the current status and challenges of bacterial combination vaccines, which will provide the reference for the development of domestic bacterial vaccines and optimization of immunization strategies.

國家重大研發(fā)計劃（2018YFC1603900）；國家自然科學基金項目（81401249）