千金子為常見中藥，含有二萜類、甾醇類、香豆素類、黃酮類、揮發(fā)油、脂肪油等豐富的化學成分和廣泛的藥物活性。二萜類化合物為其主要成分和活性成分，其中續(xù)隨子烷二萜型和巨大戟烷二萜型兩種骨架構成了千金子中的主要二萜類成分，具有致瀉、抗腫瘤、抗腫瘤多藥耐藥、調節(jié)腸道菌群、祛斑美白等多種生物活性。通過整理、分析相關文獻，全面綜述了從千金子中分離出的二萜醇酯類成分及其生物活性，并對部分生物活性作用機制以及構效關系加以介紹，為千金子二萜醇酯類成分及其生物活性方面的研究提供文獻參考，以期為更好地開發(fā)利用千金子提供科學依據。

Euphorbiae Semen is a common Chinese medicine, containing diterpenoids, sterols, coumarins, flavonoids, volatile oils, fatty oils and many other chemical components with a wide range of pharmaceutical activities. Diterpenoids are the main component and active ingredient, among which the two types of Lathyrane and Ingenane take the major part, with diarrhea, anti-tumor, antitumor multi-drug resistance, regulation of intestinal flora, ecchymosis and other biological activities. This paper comprehensively reviews the diterpenoid esters isolated from Euphorbiae Semen and their biological activities, and introduces the mechanisms of some biological acitivities and structure-activity relationships by collating and analyzing relevant literatures. It will provide a literature reference for the research on the constituents of diterpenoid esters and their biological activities, expectedly provide a scientific basis for better development and utilization of Euphorbiae Semen.

北京市自然科學基金項目（7182097）；國家自然科學基金項目（81673597）