酸漿苦素A是酸漿屬植物酸漿的主要活性成分之一，具有良好的抗腫瘤作用和抗炎作用。藥理研究表明酸漿苦素A可以顯著抑制脂多糖誘導(dǎo)巨噬細(xì)胞中一氧化氮的產(chǎn)生，從而發(fā)揮抗炎功效，作用機(jī)制可能與其修飾IκB激酶β、抑制NF-κB活性相關(guān)；還顯著抑制黑色素瘤、非小細(xì)胞肺癌、前列腺癌和肝癌腫瘤細(xì)胞的成長(zhǎng)，其抗腫瘤作用機(jī)制可能與誘導(dǎo)腫瘤細(xì)胞凋亡、抑制JAK/STAT 3信號(hào)傳導(dǎo)相關(guān)。對(duì)酸漿苦素A的藥理作用進(jìn)行綜述，旨在為進(jìn)一步開發(fā)與應(yīng)用提供文獻(xiàn)依據(jù)。

Physalin A is one of the main active constituents of Physalis alkekengi L.var. franchetii (Mast.) Makino which possesses excellent anti-tumor and anti-inflammatory activities. Pharmacological researches showed that physalin A exerted anti-inflammatory effects via significantly inhibiting the production of nitric oxide in macrophages induced by lipopolysaccharide and its mechanism of action may be related to its inhibition of NF-κB activity by modifying IκB kinase β. Additionally, physalin A obviously inhibits the growth of melanoma, non-small cell lung cancer, prostate cancer, and liver cancer tumor cells and its anti-tumor mechanism may be related to its ability to induce tumor cell apoptosis and inhibit JAK/STAT 3 signaling. This article reviews the pharmacological effects of physalin A to provide literature references for the further development and application of physalin A.

R285.5

國(guó)家自然科學(xué)基金資助項(xiàng)目（81873079）；國(guó)家重大新藥創(chuàng)制專項(xiàng)（2017ZX09301012-001）