1 differential metabolite, carries on the test, obtains the biomarker with statistical significance. Biomarkers were identified by HMDB, KEGG, metlin and other metabolite databases, and metabolic pathways were analyzed by metpa platform. Results After stimulation with EsA, HKC cells showed a decrease in cell viability (P < 0.05) and up-regulation of LDH in cell supernatant (P < 0.05), 15 biomarkers were screened by metabolomics technology and related database analysis, mainly related to glycerophospholipid metabolism, pyrimidine metabolism, sphingolipid metabolism, amino acid metabolism and energy metabolism pathway. Conclusion EsA can induce renal cell injury, may be associated with oxidative stress damage, amino acid metabolism disorders, abnormal energy metabolism, and lipid metabolism disorders."/>

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首頁 > 過刊瀏覽>2020年第43卷第3期 >2020,43(3):443-450. DOI:10.7501/j.issn.1674-6376.2020.03.013
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基于細(xì)胞代謝組學(xué)的商陸皂苷甲誘導(dǎo)HKC細(xì)胞損傷的機(jī)制研究

Mechanism research of HKC cell injury induced by esculentoside A based on cell metabolomics

發(fā)布日期:2020-03-28
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